{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:53:38Z","timestamp":1761630818229,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical outcomes are generally worse for black vs nonblack renal allograft recipients. In<jats:styled-content style=\"fixed-case\">BENEFIT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">BENEFIT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EXT<\/jats:styled-content>, recipients were randomized to belatacept more intense\u2010based, belatacept less intense\u2010based, or cyclosporine\u2010based immunosuppression. At year 7, belatacept was associated with superior graft survival vs cyclosporine in<jats:styled-content style=\"fixed-case\">BENEFIT<\/jats:styled-content>(recipients of living or standard criteria deceased donor kidneys); belatacept was associated with similar graft survival vs cyclosporine in<jats:styled-content style=\"fixed-case\">BENEFIT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EXT<\/jats:styled-content>(recipients of extended criteria donor kidneys). In both studies, renal function was superior for belatacept\u2010treated vs cyclosporine\u2010treated patients. Seven\u2010year outcomes were examined by race post hoc in each study. The effect of race and treatment on time to death or graft loss was compared using Cox regression. The interaction between treatment and race was also considered. Glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) was estimated from months 1 to 84 using a repeated\u2010measures model. In total, 8.3% (55\/666) and 13.1% (71\/543) of patients in<jats:styled-content style=\"fixed-case\">BENEFIT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">BENEFIT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EXT<\/jats:styled-content>, respectively, were black. Time to death or graft loss was similar in blacks and nonblacks. For both subgroups, estimated mean<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>increased over 7\u00a0years for belatacept, but declined for cyclosporine. Outcomes were similar in belatacept\u2010treated black and nonblack patients. Due to the small number of black patients, these results must be interpreted with caution.<\/jats:p>","DOI":"10.1111\/ctr.13225","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T19:49:08Z","timestamp":1519242548000},"source":"Crossref","is-referenced-by-count":9,"title":["Outcomes at 7\u00a0years post\u2010transplant in black vs nonblack kidney transplant recipients administered belatacept or cyclosporine in<scp>BENEFIT<\/scp>and<scp>BENEFIT<\/scp>\u2010<scp>EXT<\/scp>"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1635-9136","authenticated-orcid":false,"given":"Sander","family":"Florman","sequence":"first","affiliation":[{"name":"Recanati\/Miller Transplant Institute Mount Sinai Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Vincenti","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Surgery University of California 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