{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:02:11Z","timestamp":1761663731621,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>)\u2010related cirrhosis is a leading indication for liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) worldwide. Access to effective <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> treatment is inequitable globally. We aimed to analyze whether the introduction of effective <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> treatment caused an impact in <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> trends in a middle\u2010income country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional analysis of all adult patients who were listed\/received a <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> in Argentina for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>, alcohol\u2010related liver disease (<jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content>), or autoimmune hepatitis\/primary biliary cirrhosis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>) from 2007 to 2017. Joinpoint regression analysis was used to identify changes in the cumulative incidence rates in waiting list (<jats:styled-content style=\"fixed-case\">WL<\/jats:styled-content>) registration, <jats:styled-content style=\"fixed-case\">WL<\/jats:styled-content> mortality, and <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Liver transplantation <jats:styled-content style=\"fixed-case\">WL<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> increased significantly between 2007 and 2014, with an annual percentage change (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>) +7.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01, followed by a downward slope from 2014 to 2017 with an <jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content> \u22129.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.1. There were no significant changes in <jats:styled-content style=\"fixed-case\">WL<\/jats:styled-content> mortality. <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> trends remained stable. <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> exception points for <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> decreased (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content> \u22126.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), whereas <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> exception points increased (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content> +11.1, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Waiting list and <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> decreased, whereas <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> increased; this may be related to selective antiviral treatment access for patients with advanced fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13230","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T15:04:39Z","timestamp":1519743879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trends in liver transplantation for hepatitis C in a country with reduced access to direct\u2010acting antiviral agents"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-3561","authenticated-orcid":false,"given":"Melisa","family":"Dirchwolf","sequence":"first","affiliation":[{"name":"Liver Unit Hospital Privado de Rosario  Rosario Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e1n","family":"Marciano","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Italiano  Buenos Aires Argentina"},{"name":"Department of Research Hospital Italiano  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego H.","family":"Giunta","sequence":"additional","affiliation":[{"name":"Department of Research Hospital Italiano  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Posadas\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Research Hospital Italiano  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott W.","family":"Biggins","sequence":"additional","affiliation":[{"name":"University of Washington  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s E.","family":"Ruf","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Privado de Rosario  Rosario Argentina"},{"name":"Fundaci\u00f3n para la Docencia e Investigaci\u00f3n de las Enfermedades del H\u00edgado (FUNDIEH)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13310"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i7.352"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.185"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23744"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3361-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.144878"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28923"},{"key":"e_1_2_8_9_1","unstructured":"SolariJ VidiellaG GadanoA et\u00a0al.Indicaciones de tratamiento de VHC cr\u00f3nica con esquemas libres de interfer\u00f3n en la Argentina. 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