{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:43:14Z","timestamp":1790757794022,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>The Luminex test can detect low levels of donor\u2010specific antibody (DSA<\/jats:styled-content>) that cannot be detected by flow\u2010cytometric cross\u2010matching (FCXM<\/jats:styled-content>) in kidney transplantation (KT<\/jats:styled-content>). This study evaluated the impact of DSA<\/jats:styled-content> on clinical outcomes in KT<\/jats:styled-content> recipients negative on FCXM<\/jats:styled-content>. Of 575 consecutive patients who underwent living donor KT<\/jats:styled-content> between January 2013 and July 2016, 494 (85.9%) were DSA<\/jats:styled-content>\u2010negative and 81 (14.1%) were DSA<\/jats:styled-content>\u2010positive. Although rates of acute cellular rejection (ACR<\/jats:styled-content>) at 1\u00a0year were similar in the 2 groups (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.54), the incidence of antibody\u2010mediated rejection (ABMR<\/jats:styled-content>) was significantly higher in the DSA<\/jats:styled-content>\u2010positive group (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.01). There was no statistically significant association between rejection\u2010free graft survival (RFGS<\/jats:styled-content>) rates and pretransplant class I DSA<\/jats:styled-content>. However, evaluation of pretransplant class II DSA<\/jats:styled-content> showed that RFGS<\/jats:styled-content> rates were significantly lower in patients with mean fluorescence intensity (MFI<\/jats:styled-content>) >3000 than in patients with DSA<\/jats:styled-content>\u2010negative (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.01). On multivariate analyses, class II DSA MFI<\/jats:styled-content> \u22655000 was a significant risk factor for acute rejection (hazard ratio, 7.48; P\u00a0<\u00a0<\/jats:italic>.01). These findings suggested that pretransplant DSA<\/jats:styled-content> alone did not affect graft survival in KT<\/jats:styled-content> recipients without desensitization. However, class II DSA MFI<\/jats:styled-content> >5000 was an independent predictor of acute rejection in DSA<\/jats:styled-content>\u2010positive patients.<\/jats:p>","DOI":"10.1111\/ctr.13266","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T14:14:46Z","timestamp":1524233686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of pretransplant donor\u2010specific antibodies on kidney allograft recipients with negative flow cytometry cross\u2010matches"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5018-5304","authenticated-orcid":false,"given":"Hyunwook","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young 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