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Both conditions lead to extrarespiratory complications, such as diabetes, renal insufficiency, bone disease, and cancer. The purpose of this study was to provide an update of the nonrespiratory comorbidities following <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> in adult patients with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> and their specificities regarding their multisystemic underlying condition despite their younger age compared to other patients undergoing <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>. Diabetes, renal insufficiency, metabolic bone disease, hypertension, liver disease, and cancer are the comorbidities considered in this review. 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