{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:41Z","timestamp":1772160101477,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Chagas cardiomyopathy (\n CC<\/jats:styled-content>\n ) is one of the chronic manifestations of\n Trypanosoma cruzi<\/jats:italic>\n (\n T.\u00a0cruzi<\/jats:italic>\n ) infection and is among the leading reasons for heart transplantation (\n HT<\/jats:styled-content>\n ) in Latin America. Chagas disease is also present in areas with large Hispanic communities in the United States. Our objective is to evaluate the outcomes of cardiac allograft recipients with the diagnosis of\n CC<\/jats:styled-content>\n in the United States.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We identified 25 adult patients with\n CC<\/jats:styled-content>\n and 15\u00a0930 with idiopathic dilated cardiomyopathy (\n IDCMP<\/jats:styled-content>\n ) who underwent\n HT<\/jats:styled-content>\n between 1987 and 2015.\n CC<\/jats:styled-content>\n patients were mostly Hispanics, had lower mean pulmonary artery pressure (23 vs 29\u00a0mm\u00a0Hg,\n P<\/jats:italic>\n \u00a0=\u00a0.035) and lower\n BMI<\/jats:styled-content>\n (24 vs 26,\n P<\/jats:italic>\n \u00a0=\u00a0.007). Patients with\n CC<\/jats:styled-content>\n were more likely to be supported with a total artificial heart (\n TAH<\/jats:styled-content>\n ) as bridge to transplant (\n P<\/jats:italic>\n \u00a0=\u00a0.009). There were no statistical differences for overall mortality and graft survival between\n CC<\/jats:styled-content>\n and\n IDCMP<\/jats:styled-content>\n cardiac allograft recipients. Induction therapy and mycophenolate mofetil (\n MMF<\/jats:styled-content>\n ) use were associated with higher rate of infection in Chagas patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Heart transplantation recipients with\n CC<\/jats:styled-content>\n diagnosis appear to have similar outcomes to\n IDCMP<\/jats:styled-content>\n patients. Induction therapy and\n MMF<\/jats:styled-content>\n use may be associated with higher risk of infection in\n CC<\/jats:styled-content>\n patients who underwent transplantation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ctr.13279","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T20:29:36Z","timestamp":1525897776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Heart transplant outcomes in patients with Chagas cardiomyopathy in the United States"],"prefix":"10.1111","volume":"32","author":[{"given":"Rodolfo D.","family":"Benatti","sequence":"first","affiliation":[{"name":"Advanced Heart Failure and Transplant Center Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1122-7695","authenticated-orcid":false,"given":"Sadeer G.","family":"Al\u2010Kindi","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Transplant Center Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Bacal","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme H.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Transplant Center Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/605091"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002229"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.02.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2011000600002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12507"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02587-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00975.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.02.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03444.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1014204"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2003.05.003"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T20:38:38Z","timestamp":1695415118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/ctr.13279"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13279","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733243948.793562579","asserted-by":"object"}]},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"2018-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13279"}}