{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:00:29Z","timestamp":1778817629157,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In this study, we aimed to determine the frequency of histopathologic outcomes of solid\u2010organ transplantation in women with abnormal uterine bleeding (<jats:styled-content style=\"fixed-case\">AUB<\/jats:styled-content>) receiving immunosuppressive therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study including a single\u2010center experience. Data were extracted from hospital records, and solid\u2010organ transplant recipients who were diagnosed with <jats:styled-content style=\"fixed-case\">AUB<\/jats:styled-content> were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five of these patients were renal transplant recipients (79.7%), and 14 were liver transplant recipients (20.3%). Histopathologic examination showed various histopathologic patterns of endometrium in patients with <jats:styled-content style=\"fixed-case\">AUB<\/jats:styled-content> consisting of normal histopathologic findings of endometrium in 31 patients (48.4%); 29 hormonal imbalance during proliferative and secretory phases of menstrual cycle and two atrophic endometrium. Endometrial hyperplasia without atypia was observed in 11 patients (17.2%). Polyp was seen in 22 patients (34.4%); 21 endometrial polyp and one endocervical polyp. There were significant differences in terms of histopathologic findings among the three groups of patients according to different immunosuppressive regimens (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.029). There was no endometrial hyperplasia in women receiving sirolimus\u2010based immunosuppressive regimens. Moreover, there was no endometrial hyperplasia in the liver transplant recipient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sirolimus\u2010based immunosuppressive regimens may be administered to patients who have risk factors for endometrial precancerous lesions, such as endometrial hyperplasia. However, additional well\u2010designed, large\u2010scale studies are warranted to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13305","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T07:36:00Z","timestamp":1527752160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Possible impact of immunosuppressive therapy regimens on histopathologic outcomes of abnormal uterine bleeding in solid\u2010organ transplant recipients"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-4733","authenticated-orcid":false,"given":"Yusuf Aytac","family":"Tohma","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Baskent University School of Medicine  Ankara 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Yagmur","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Baskent University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hulusi Bulent","family":"Zeyneloglu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Kuscu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Baskent University School of Medicine  Ankara 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