{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:34:06Z","timestamp":1765280046972,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current mismatch between supply and demand of organs has prompted transplant clinicians to consider innovative solutions to broaden the donor pool. Advancements of direct\u2010acting antiviral agent (DAA) therapy for hepatitis C virus (HCV) have allowed entertaining the use of viremic donor organs in nonviremic recipients. In this report, we describe the evolution of HCV treatment, ethics and informed consent, cost\u2010effectiveness of HCV medications in treating acute HCV post\u2010transplantation, and the Stanford experience with two HCV\u2010viremic donor heart transplantations. We describe excellent short\u2010term outcomes post\u2013heart transplantation with HCV NAT\u2010positive organs. The availability of this therapy may expand the donor pool. While we await larger\u2010scale clinical data on the effectiveness and safety of DAA therapy in patients after heart transplantation, many transplant centers have already started accepting organs from HCV\u2010infected donors, balancing the unknown long\u2010term risks versus the benefits of shorter wait times and expansion of the donor pool. Protocols and multidisciplinary teams are needed to effectively communicate risk to potential recipients, to ensure timely DAA access, and to implement appropriate clinical follow\u2010up in order to achieve excellent clinical outcomes and to maximize the donor pool by utilizing HCV\u2010infected organs for heart transplantation.<\/jats:p>","DOI":"10.1111\/ctr.13308","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T07:59:34Z","timestamp":1528185574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Accepting hepatitis C virus\u2013infected donor hearts for transplantation: Multistep consent, unrealized opportunity, and the Stanford experience"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-7393","authenticated-orcid":false,"given":"Yasbanoo","family":"Moayedi","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Heart Transplantation Stanford University  Stanford CA USA"},{"name":"Ted Rogers Centre of Excellence in Heart Function Peter Munk Cardiac Centre University Health Network  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliya F.","family":"Gulamhusein","sequence":"additional","affiliation":[{"name":"Toronto Centre for Liver Disease University Health Network  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather J","family":"Ross","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre of Excellence in Heart Function Peter Munk Cardiac Centre University Health Network  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey J.","family":"Teuteberg","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Heart Transplantation Stanford University  Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran K.","family":"Khush","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Heart Transplantation Stanford University  Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2017.08.448"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14381"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14396"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1611829"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.09.008"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T14:13:38Z","timestamp":1695046418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/ctr.13308"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13308","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2018,6,21]]},"assertion":[{"value":"2018-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13308"}}