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Although several hurdles remain, the use of rapidly evolving transgenic technology has the potential to address current allogeneic donor pool constraints and mechanical circulatory system device limitations. The success of xenotransplantation will undoubtedly be dependent on specific patient selection criteria. Defining these particular indications for xenotransplantation is important as we approach the possibility of clinical applications.<\/jats:p>","DOI":"10.1111\/ctr.13330","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T08:39:16Z","timestamp":1530261556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Consideration of appropriate clinical applications for cardiac xenotransplantation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-561X","authenticated-orcid":false,"given":"Joshua L.","family":"Chan","sequence":"first","affiliation":[{"name":"Cardiothoracic Surgery Research Program\/National Heart Lung and Blood Institute National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin G.","family":"Miller","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Research Program\/National Heart Lung and Blood Institute National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avneesh K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Research Program\/National Heart Lung and Blood Institute National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A.","family":"Horvath","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Research Program\/National Heart Lung and Blood Institute National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip C.","family":"Corcoran","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Research Program\/National Heart Lung and Blood Institute National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-783X","authenticated-orcid":false,"given":"Muhammad M.","family":"Mohiuddin","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Research Program\/National Heart Lung and Blood Institute National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,29]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"National hospital discharge survey: 2007 summary","volume":"29","author":"Hall MJ","year":"2010","journal-title":"Natl Health Stat Report"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.131.suppl_2.o29"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2009.09.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7133.2011.00236.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/heart.87.2.177","article-title":"Cardiac transplantation","volume":"87","author":"Deng MC","year":"2002","journal-title":"Heart"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13199"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.11.067"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12176"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.05.117"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03846.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12066"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2012.00697.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11138"},{"key":"e_1_2_8_15_1","first-page":"1120","article-title":"Adult heart transplant: indications and outcomes","volume":"6","author":"Alraies MC","year":"2014","journal-title":"J Thorac Dis"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300048"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1001\/jama.1993.03510200075035","article-title":"Rationing failure. 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