{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:54:20Z","timestamp":1777449260834,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["5274"],"award-info":[{"award-number":["5274"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>Successful eradication of recurrent hepatitis C virus (HCV<\/jats:styled-content>) infection following liver transplantation (HCV<\/jats:styled-content>) improves graft survival. This study aimed at evaluation of hepatic fibrosis changes among long\u2010term responders to DAA<\/jats:styled-content> therapy for recurrent HCV<\/jats:styled-content> after liver transplantation using noninvasive methods. Patients with significant hepatic fibrosis (\u2265F2) who achieved SVR<\/jats:styled-content>12 after treatment with DAA<\/jats:styled-content>s for recurrent HCV<\/jats:styled-content> were included (n\u00a0=\u00a052). Hepatic fibrosis status was assessed, noninvasively, by calculation of fibrosis\u20104 score (FIB<\/jats:styled-content>\u20104) and Aspartate Aminotransferase Platelet Ratio Index (APRI<\/jats:styled-content>) and by measurement of graft stiffness using FibroScan at baseline and 12 and 18\u00a0months post\u2010treatment. Acoustic radiation force imaging (ARFI<\/jats:styled-content>) was done for all patients 12 and 18\u00a0months post\u2010treatment. Patients were classified into two groups based on baseline liver stiffness measurement (LSM<\/jats:styled-content>) by FibroScan; significant fibrosis (F2; n\u00a0=\u00a028) and advanced fibrosis groups (\u2265F3). Over 18\u2010month follow\u2010up period, there was serial improvement of FIB<\/jats:styled-content>\u20104, APRI<\/jats:styled-content>, and LSM<\/jats:styled-content> by FibroScan in both groups. Higher baseline LSM<\/jats:styled-content> and delayed initiation of antiviral therapy were significant predictors of lack of fibrosis regression (P<\/jats:italic>\u2010value 0.01 and 0.04, respectively). Fibroindices and LSM<\/jats:styled-content> improved over time in liver transplant recipients who responded to DAA<\/jats:styled-content>s. Baseline LSM<\/jats:styled-content> can predict post\u2010treatment fibrosis regression.<\/jats:p>","DOI":"10.1111\/ctr.13334","type":"journal-article","created":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T11:35:46Z","timestamp":1529753746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Longitudinal assessment of hepatic fibrosis in responders to direct\u2010acting antivirals for recurrent hepatitis C after liver transplantation using noninvasive methods"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9707-1141","authenticated-orcid":false,"given":"Heba","family":"Omar","sequence":"first","affiliation":[{"name":"Endemic Medicine and Hepatology Department Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Said","sequence":"additional","affiliation":[{"name":"Endemic Medicine and 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