{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:30:48Z","timestamp":1761514248443,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T00:00:00Z","timestamp":1535241600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monoclonal B\u2010cell lymphocytosis (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>) is a lymphoproliferative disorder characterized by clonal expansion of a B\u2010cell population in peripheral blood of otherwise healthy subjects. <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> is divided into <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> (chronic lymphocytic leukemia)\u2010like, atypical <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\u2010like and non\u2010<jats:styled-content style=\"fixed-case\">CLL MBL<\/jats:styled-content>. The aim of this study was to evaluate immunophenotypic characteristics and clinical outcomes of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> in kidney transplant (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>) recipients. We retrospectively evaluated 593 kidney transplant (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>) recipients in follow\u2010up at our center. Among them, 157 patients underwent peripheral blood flow cytometry for different clinical indications. A 6\u2010color panel flow cytometry was used to diagnose <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>. This condition was detected in 5 of 157 <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> recipients. Immunophenotypic characterization of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> showed four cases of non\u2010<jats:styled-content style=\"fixed-case\">CLL MBL<\/jats:styled-content> and one case of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\u2010like <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>. At presentation, median age was 65\u00a0years (range 61\u201073). After a median follow\u2010up of 3.1\u00a0years (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>; 1.1\u20105) from diagnosis, patients did not progress either to <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> or to lymphoma. The disorder did not increase the risk of malignancy, severe infections, graft loss and mortality among our <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> recipients. Surprisingly, all cases were also affected by concomitant monoclonal gammopathy of undetermined significance, which did not progress to multiple myeloma during follow\u2010up. In conclusion, our data suggest that <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> is an age\u2010related disorder, with non\u2010<jats:styled-content style=\"fixed-case\">CLL MBL<\/jats:styled-content> being the most common subtype among <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> recipients.<\/jats:p>","DOI":"10.1111\/ctr.13338","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T05:42:56Z","timestamp":1533620576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunophenotypic profile and clinical outcome of monoclonal B\u2010cell lymphocytosis in kidney transplantation"],"prefix":"10.1111","volume":"32","author":[{"given":"Gaetano","family":"Alfano","sequence":"first","affiliation":[{"name":"Section of Nephrology Surgical, Medical and Dental Department of Morphological Sciences University of Modena and Reggio Emilia, Azienda 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Policlinico  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Ligabue","sequence":"additional","affiliation":[{"name":"Section of Nephrology Surgical, Medical and Dental Department of Morphological Sciences University of Modena and Reggio Emilia, Azienda Ospedaliero \u2010 Universitaria Policlinico  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Messerotti","sequence":"additional","affiliation":[{"name":"Section of Hematology Surgical, Medical and Dental Department of Morphological Sciences University of Modena and Reggio Emilia, Azienda Ospedaliero \u2010 Universitaria Policlinico  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Bettelli","sequence":"additional","affiliation":[{"name":"Section of Hematology Surgical, Medical and Dental Department of Morphological Sciences University of Modena and Reggio Emilia, Azienda Ospedaliero \u2010 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