{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:41:00Z","timestamp":1790995260015,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A growing number of publications have reported the outbreaks of post\u2010transplant pneumocystis pneumonia (<jats:styled-content style=\"fixed-case\">PJP<\/jats:styled-content>). In most studies, the onset of <jats:styled-content style=\"fixed-case\">PJP<\/jats:styled-content> was beyond 6\u201012\u00a0months of prophylaxis. Cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) infection and allograft rejection have been repeatedly reported as probable risk factors for post\u2010transplant <jats:styled-content style=\"fixed-case\">PJP<\/jats:styled-content>. In this systematic review and meta\u2010analysis, we determined the pooled effect estimates of these 2 variables as risk factors. Data sources included PUBMED, MEDLINE\u2010OVID, EMBASE\u2010OVID, Cochrane Library, Networked Digital Library of Theses and Dissertations, World Health Organization, and Web of Science. We excluded publications related to hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) or Human Immunodeficiency Virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) patients. Eventually, 15 studies remained for the final stage of screening. Cytomegalovirus infection (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.30, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95%: 2.07\u20105.26, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 57%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and allograft rejection (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>:2.36, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>95%: 1.54\u20103.62, I2: 45.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) significantly increased the risk of post\u2010transplant <jats:styled-content style=\"fixed-case\">PJP<\/jats:styled-content>. Extended prophylaxis targeting recipients with allograft rejection or <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection may reduce the risk of <jats:styled-content style=\"fixed-case\">PJP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ctr.13339","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T07:34:35Z","timestamp":1530257675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Cytomegalovirus infection and graft rejection as risk factors for pneumocystis pneumonia in solid organ transplant recipients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-2458","authenticated-orcid":false,"given":"Seyed M.","family":"Hosseini\u2010Moghaddam","sequence":"first","affiliation":[{"name":"MultiOrgan Transplant Program Division of Infectious Diseases Department of Medicine London Health Sciences Centre Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohin Jayaram","family":"Krishnan","sequence":"additional","affiliation":[{"name":"The Department of Epidemiology&amp; Biostatistics Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"The Department of Epidemiology&amp; Biostatistics Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1961-0477","authenticated-orcid":false,"given":"Deepali","family":"Kumar","sequence":"additional","affiliation":[{"name":"Multiorgan Transplant Program Toronto General Hospital University Health Network University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-76"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181aad256"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.02.107"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12119"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2012.00740.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2012.00739.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12184"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00366.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2014.09.010"},{"key":"e_1_2_6_11_1","unstructured":"SeyedMH\u2010M GurbirS Anthony JevnikarAH.Late Onset Cluster of Pneumocystis jirovecii pneumonia (PJP) in renal transplant patients: re\u2010examining prophylaxis strategies. In: Pennsylvania ed. American Transplant Congress. Philadelphia: ATC2015:Abstract number: 1476.http:\/\/www.atcmeetingabstracts.com\/abstract\/late-onset-cluster-of-pneumocystis-jirovecii-pneumonia-pjp-in-renal-transplant-patients-re-examining-prophylaxis-strategies\/. 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