{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:08:37Z","timestamp":1768532917229,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,22]],"date-time":"2018-07-22T00:00:00Z","timestamp":1532217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent serosal inflammation with fever, which can result in amyloid deposition. Anti\u2010interleukin\u20101 drugs emerge as a therapeutic option for colchicine\u2010resistant patients. In this study, we aimed to document our experience with canakinumab use in kidney transplant recipients who developed AA amyloidosis due to FMF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of nine patients with FMF amyloidosis treated with canakinumab were enrolled. Laboratory and clinical data were collected from the patient files, electronic database of the hospital and with interviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five of the patients were male and four were female (median age: 33, range: 27\u201062\u00a0years). All of the patients had rapid or gradual disappearance of FMF attacks. The following changes in the laboratory parameters were observed before and after the treatment: C\u2010reactive protein: 18.31\u00a0\u00b1\u00a013.58\u00a0mg\/L vs 9.98\u00a0\u00b1\u00a011.66\u00a0mg\/L, creatinine clearance: 45.27\u00a0\u00b1\u00a021.5\u00a0mL\/min vs 50.71\u00a0\u00b1\u00a022.48\u00a0mL\/min, and 24\u2010hour proteinuria: 2381.8\u00a0\u00b1\u00a03910.4\u00a0mg vs 710.0\u00a0\u00b1\u00a01117.5\u00a0mg; there were no statistically significant differences on those parameters. One patient developed a reaction to injection while another showed symptoms of Cytomegalovirus pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Canakinumab can be considered as a safe and efficient drug in preventing the FMF attacks in kidney transplant recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13345","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T15:03:07Z","timestamp":1530975787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Canakinumab treatment in kidney transplant recipients with AA amyloidosis due to familial Mediterranean fever"],"prefix":"10.1111","volume":"32","author":[{"given":"Sinan","family":"Trabulus","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Cerrahpasa Medical Faculty Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cerrahpasa Medical Faculty Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eda","family":"Kaya","sequence":"additional","affiliation":[{"name":"Cerrahpasa Medical Faculty Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7427-618X","authenticated-orcid":false,"given":"Nurhan","family":"Seyahi","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Cerrahpasa Medical Faculty Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-3-319-14615-7_9","volume-title":"Familial Mediterranean Fever","author":"Ozdogan H","year":"2015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000152370.84628.0c"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket400"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(01)02461-7"},{"issue":"2","key":"e_1_2_7_6_1","first-page":"154","article-title":"Current status of renal replacement therapies in Turkey: Turkish society of nephrology registry 2015 summary report","volume":"26","author":"Suleymanlar G","year":"2017","journal-title":"Turk Nephrol Dial 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