{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:40Z","timestamp":1772160100316,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Evaluation of potential kidney transplant recipients is important to identify and treat conditions that may influence graft or patient survival after transplantation. We performed a single\u2010center, observational cohort study to determine whether pretransplant midodrine use influences outcomes after kidney transplantation. We analyzed graft and patient outcomes for adult patients who underwent a kidney\u2010only transplantation at Barnes\u2010Jewish Hospital from January 1999 to December 2015. We quantified adjusted associations of pretransplant midodrine use with post\u2010transplant complications by multivariable Cox regression. Among the 2621 kidney transplant recipients analyzed, 37 (1.4%) were taking midodrine immediately prior to transplantation. Midodrine users were more commonly older (56.5 vs 50.4\u00a0years) and obese (67.6% vs 33.6%). Midodrine users were also more likely to be on hemodialysis (86.5% vs 59.2%), to have a longer duration of dialysis dependence (646\u00a0months vs 577\u00a0months), and to have higher levels of sensitization (peak panel reactive antibody &gt;20%, 32.4% vs 15.8%) compared to nonusers. Pretransplant midodrine users had significantly higher rates of delayed graft function (DGF) (32.4% vs 6.7%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). No difference in the incidence of DGF was observed based on the midodrine dosing regimen. After multivariable adjustment for recipient and donor characteristics, pretransplant midodrine use was independently associated with graft failure at 1\u00a0year (adjusted hazard ratio, 5.11; 95% confidence interval, 2.09\u201012.49).\n                  <\/jats:p>","DOI":"10.1111\/ctr.13366","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T02:37:15Z","timestamp":1533609435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of pretransplant midodrine use on outcomes after kidney transplantation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4072-5121","authenticated-orcid":false,"given":"April A.","family":"Pottebaum","sequence":"first","affiliation":[{"name":"Department of Pharmacy Barnes\u2010Jewish Hospital  St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer C.","family":"Hagopian","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Barnes\u2010Jewish Hospital  St. Louis Missouri"},{"name":"Department of Medicine, Division of Nephrology Washington University School of Medicine  St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Medicine The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ara","family":"Gharabagi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology Washington University School of Medicine  St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy A.","family":"Horwedel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Barnes\u2010Jewish Hospital  St. Louis Missouri"},{"name":"Department of Medicine, Division of Nephrology Washington University School of Medicine  St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.08.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001113"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh420"},{"key":"e_1_2_8_5_1","volume-title":"Midodrine (prescribing information)","author":"Sandoz Inc","year":"2014"},{"issue":"4","key":"e_1_2_8_6_1","first-page":"261","article-title":"Midodrine treatment for patients with hemodialysis hypotension","volume":"45","author":"Flynn JJ","year":"1996","journal-title":"Clin Nephrol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000190288"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"101","article-title":"Midodrine is effective and safe therapy for intradialytic hypotension over 8\u00a0months of follow\u2010up","volume":"50","author":"Cruz DN","year":"1998","journal-title":"Clin Nephrol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200305000-00002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12138"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00812.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm019"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007020199"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl042"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.07.038"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn667"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.03.014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2016.06.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001323"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200010150-00018"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh1013"}],"container-title":["Clinical 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