{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:53:55Z","timestamp":1761630835088,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The opioid epidemic has resulted in a potential increase in donors in the testing window period for hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>). We analyzed <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> reports to the Disease Transmission Advisory Committee (<jats:styled-content style=\"fixed-case\">DTAC<\/jats:styled-content>) between 2008 and 2016 to estimate the risk of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> transmission. In 15 of 95 (16%) reports, at least one recipient developed proven\/probable donor\u2010derived <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> resulting in 32 infected recipients. Seven transmissions occurred during the nucleic acid testing (<jats:styled-content style=\"fixed-case\">NAT<\/jats:styled-content>) window period; four occurred during serological window period. The other four transmission occurred due to human error (3) and false\u2010negative serology (1). All seronegative\u2010exposed liver and lung recipients contracted <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>; 18\/21 (86%) kidney and 3\/4 (75%) heart recipients developed <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. Four transmitting donors died of intravenous drug overdose, three in 2016 and one in 2012. Among donors with a history of intravenous drug use (<jats:styled-content style=\"fixed-case\">IVDU<\/jats:styled-content>), drug intoxication as a mechanism of death, or increased risk status, and negative screening <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> testing, the risk of transmission to a recipient was about 1 in 1000. The overall risk of transmitting <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">NAT<\/jats:styled-content>\u2010negative donors with <jats:styled-content style=\"fixed-case\">IVDU<\/jats:styled-content> is low and consistent with modeling data. This information may be helpful to clinicians counseling potential recipients offered these organs.<\/jats:p>","DOI":"10.1111\/ctr.13370","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T10:34:28Z","timestamp":1533638068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Donor\u2010derived hepatitis C in the era of increasing intravenous drug use: A report of the Disease Transmission Advisory Committee"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-4148","authenticated-orcid":false,"given":"Daniel R.","family":"Kaul","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases University of Michigan Medical School  Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Tlusty","sequence":"additional","affiliation":[{"name":"United Network for Organ Sharing  Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian G.","family":"Michaels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Infectious Diseases University of Pittsburgh School of Medicine Children's Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit P.","family":"Limaye","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Allergy and Infectious Disease University of Washington School of Medicine  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron R.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases Duke University Medical School  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Centers for Disease Control and Prevention.Vital Signs Today's Heroin Epidemic.2015.https:\/\/www.cdc.gov\/vitalsigns\/heroin\/. 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