{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T14:19:21Z","timestamp":1768141161754,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T00:00:00Z","timestamp":1536969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32DK007568\u201025"],"award-info":[{"award-number":["5T32DK007568\u201025"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) serotyping is not considered to have significant impact on liver graft survival and does not factor into U.S. organ allocation. Immune\u2010related liver diseases such as primary sclerosing cholangitis (<jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>), autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>), and primary biliary cholangitis (<jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>) have been speculated to represent a disease subgroup that may have significantly different graft outcomes depending on <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> donor\/recipient characterization. The aim of this study was to investigate whether <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> serotyping\/matching influenced post\u2010transplant graft failure for immune\u2010related liver diseases using the United Network for Organ Sharing database. From 1994 to 2015, 5665 patients underwent first\u2010time liver\u2010only transplants for <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AIH<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> with complete graft survival and donor\/recipient <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> data. Graft failure was noted in 38.6% (2188\/5665), and all groups had comparable 5\u2010year graft survival (75.1%\u201078.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.069). The overall degree of, and loci\u2010specific mismatch level, did not influence outcomes. Multivariable Cox proportional hazards regression noted increased graft failure risk for recipient <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B7, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B57, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B75, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>13 and donor <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B55, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B58, and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>8 for <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> patients, protective effects for recipient <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>3 for <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients, and increased risk for <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>7 for <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients. These findings warrant further investigation to evaluate the impact of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> serotyping on post\u2010transplant outcomes.<\/jats:p>","DOI":"10.1111\/ctr.13388","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T07:13:54Z","timestamp":1535008434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The impact of human leukocyte antigen donor and recipient serotyping and matching on liver transplant graft failure in primary sclerosing cholangitis, autoimmune hepatitis, and primary biliary cholangitis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-3983","authenticated-orcid":false,"given":"Yuval A.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Duke University School of Medicine  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline B.","family":"Henson","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius M.","family":"Wilder","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Duke University School of Medicine  Durham North Carolina"},{"name":"Duke Clinical Research Institute Duke University School of Medicine  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schein\u2010Chung","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl L.","family":"Berg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Duke University School of Medicine  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1625-385X","authenticated-orcid":false,"given":"Stuart J.","family":"Knechtle","sequence":"additional","affiliation":[{"name":"Duke Transplant Center Department of Surgery Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Muir","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Duke University School of Medicine  Durham North Carolina"},{"name":"Duke Clinical Research Institute Duke University School of Medicine  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199410150-00006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1996.tb00642.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199602150-00022"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199807150-00009"},{"issue":"3","key":"e_1_2_7_6_1","first-page":"372","article-title":"Histocompatibility and liver transplant outcome. Does HLA exert a dualistic effect?","volume":"46","author":"Markus BH","year":"1988","journal-title":"Transplantation"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840170611"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20680"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200004150-00047"},{"issue":"5","key":"e_1_2_7_10_1","first-page":"2144","article-title":"Determinants of successful liver transplantation","volume":"22","author":"Sheil AG","year":"1990","journal-title":"Transpl Proc"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.1.38"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528209182038"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2016.7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2014.82"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2014.03.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24414"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21394"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.21449"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000090867.83666.F7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200301150-00024"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22435"},{"issue":"4","key":"e_1_2_7_22_1","first-page":"667","article-title":"Histocompatibility and liver transplantation","volume":"114","author":"Knechtle SJ","year":"1993","journal-title":"Surgery"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22161"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20678"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2000.18480"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.07.035"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.041"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00772.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1996.tb02593.x"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T03:48:46Z","timestamp":1694836126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,15]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/ctr.13388"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13388","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,15]]},"assertion":[{"value":"2017-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13388"}}