{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:48:12Z","timestamp":1758638892390,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T00:00:00Z","timestamp":1537660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the incidence of acute kidney injury (AKI) and its common etiologies in kidney transplant recipients and the effect of AKI's characteristics on graft survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective longitudinal cohort study, all serum creatinine (SCr) values of patients that had kidney transplantation between 01\/2002\u201012\/2010 were retrieved. AKI was defined as a 50% increase in SCr. Etiologies, recurrence, timing, and kidney function dynamics during the event were evaluated. The primary endpoint was defined as graft loss. Time\u2010varying Cox model was used for the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 659 patients, 208 (31.6%) patients had 321 documented AKI events. Of these, 138 (66.4%) patients had one event, and 70 (33.6%) patients had recurrent events. The leading etiologies of the first AKI event were as follows: infection (33.4%), hypovolemia (14.3%), and unknown etiology (16.8%). Both first and recurrent AKI events were associated with an increased risk of graft loss (HR: 2.76, 95% CI: 1.95\u20103.89) and (HR: 4.54, 95% CI: 2.59\u20107.93), respectively. This deleterious association was lower within three months after transplantation, compared to later events. Patients in whom kidney function returned to baseline were less prone to graft loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Late\u2010onset, incomplete recovery, and recurrent AKI events are associated with increased graft loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13398","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T06:49:17Z","timestamp":1535957357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of cause, timing, kidney function recovery, and recurrent events on the prognosis of acute kidney injury in kidney transplant recipients"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-0482","authenticated-orcid":false,"given":"Tuvya Y.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Internal Medicine D Rabin Medical Center Petah\u2010Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010 Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Rahamimov","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010 Aviv University Tel\u2010Aviv Israel"},{"name":"Department of Nephrology and Hypertension Rabin Medical Center Petah\u2010Tikva Israel"},{"name":"Department of Transplantation Rabin Medical Center Petah\u2010 Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avry","family":"Chagnac","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010 Aviv University Tel\u2010Aviv Israel"},{"name":"Department of Nephrology and Hypertension Rabin Medical Center Petah\u2010Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010 Aviv University Tel\u2010Aviv Israel"},{"name":"Department of Nephrology and Hypertension Rabin Medical Center Petah\u2010Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eytan","family":"Mor","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010 Aviv University Tel\u2010Aviv Israel"},{"name":"Department of Transplantation Rabin Medical Center Petah\u2010 Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Shlomai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine D Rabin Medical Center Petah\u2010Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010 Aviv University Tel\u2010Aviv Israel"},{"name":"The Liver Institute Rabin Medical Center Petah\u2010Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benaya","family":"Rozen\u2010Zvi","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010 Aviv University 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