{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:30:31Z","timestamp":1759336231982,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transplant glomerulopathy (TG) is an important cause of late graft loss. The role of angiotensin type 1\u2010receptor antibodies (AT<jats:sub>1<\/jats:sub>R\u2010Ab) in TG is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All the TG cases (N\u00a0=\u00a0137) between January 2007 and December 2014 (N\u00a0=\u00a01410) were analyzed. Donor\u2010specific anti\u2010HLA antibodies (DSA) at the time of biopsy and AT<jats:sub>1<\/jats:sub>R\u2010Ab IgG (positive, &gt;17\u00a0UI\/mL; \u201cat risk,\u201d 10\u201017\u00a0UI\/mL; negative, &lt;10\u00a0UI\/mL) in pre\u2010transplant sera (PT\u2010Ab) and at biopsy time (BT\u2010Ab) were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AT<jats:sub>1<\/jats:sub>R\u2010PT\u2010Ab<jats:sup>+<\/jats:sup> and AT<jats:sub>1<\/jats:sub>R\u2010BT\u2010Ab<jats:sup>+<\/jats:sup> patients were 16.5% (51.5% \u201cat risk\u201d) and 11.5% (27.4% \u201cat risk\u201d), respectively. Clinical correlations were found between AT<jats:sub>1<\/jats:sub>R\u2010Ab and HCV infection, number of transplants, and age. Considering Banff scores, ptc was higher in DSA<jats:sup>+<\/jats:sup> patients vs AT<jats:sub>1<\/jats:sub>R\u2010PT\u2010Ab<jats:sup>+<\/jats:sup> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) or AT<jats:sub>1<\/jats:sub>R\u2010BT\u2010Ab<jats:sup>+<\/jats:sup> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) without differences in g and chronicity score (ci\u00a0+\u00a0ct); cg showed lower scores in DSA<jats:sup>+<\/jats:sup> patients vs AT<jats:sub>1<\/jats:sub>R\u2010BT\u2010Ab<jats:sup>+<\/jats:sup> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Graft survival was not influenced by the presence of AT<jats:sub>1<\/jats:sub>R\u2010Ab, AT1\u2010R\u2010Ab titer or MFI, but we observed a longer graft survival in patients with both AT<jats:sub>1<\/jats:sub>R\u2010BT\u2010Ab<jats:sup>+<\/jats:sup> or \u201cat risk\u201d and DSA<jats:sup>+<\/jats:sup> vs patients positive only for DSA (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), for AT<jats:sub>1<\/jats:sub>R\u2010BT\u2010Ab (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.019) or AT<jats:sub>1<\/jats:sub>R\u2010BT\u2010Ab \u201cat risk\u201d (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AT<jats:sub>1<\/jats:sub>R\u2010Ab showed no independent prognostic role in TG in this pilot analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13407","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T13:13:42Z","timestamp":1537103622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Detection of Angiotensin II type I\u2010receptor antibodies in transplant glomerulopathy"],"prefix":"10.1111","volume":"32","author":[{"given":"Stefania","family":"Bussolino","sequence":"first","affiliation":[{"name":"Division of Nephrology and Dialysis ASO Civico Chivasso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Dolla","sequence":"additional","affiliation":[{"name":"Renal Transplantation Center, \u201cA. Vercellone\u201d, Division of Nephrology Dialysis and Transplantation, Citt\u00e0 della Salute e della Scienza Hospital and Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Ariaudo","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis ASO S. Croce e Carle Cuneo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Civiletti","sequence":"additional","affiliation":[{"name":"Renal Transplantation Center, \u201cA. Vercellone\u201d, Division of Nephrology Dialysis and Transplantation, Citt\u00e0 della Salute e della Scienza Hospital and Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Messina","sequence":"additional","affiliation":[{"name":"Renal Transplantation Center, \u201cA. Vercellone\u201d, Division of Nephrology Dialysis and Transplantation, Citt\u00e0 della Salute e della Scienza Hospital and Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Mella","sequence":"additional","affiliation":[{"name":"Renal Transplantation Center, \u201cA. Vercellone\u201d, Division of Nephrology Dialysis and Transplantation, Citt\u00e0 della Salute e della Scienza Hospital and Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Caorsi","sequence":"additional","affiliation":[{"name":"Immunogenetic and Transplant Biology Center, Citt\u00e0 della Salute e della Scienza Hospital and Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Amoroso","sequence":"additional","affiliation":[{"name":"Immunogenetic and Transplant Biology Center, Citt\u00e0 della Salute e della Scienza Hospital and Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Barreca","sequence":"additional","affiliation":[{"name":"Pathology Division, Department of Oncology University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Papotti","sequence":"additional","affiliation":[{"name":"Pathology Division, Department of Oncology University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Giunti","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Fop","sequence":"additional","affiliation":[{"name":"Renal Transplantation Center, \u201cA. Vercellone\u201d, Division of Nephrology Dialysis and Transplantation, Citt\u00e0 della Salute e della Scienza Hospital and Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1900-1156","authenticated-orcid":false,"given":"Luigi","family":"Biancone","sequence":"additional","affiliation":[{"name":"Renal Transplantation Center, \u201cA. 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