{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:55:18Z","timestamp":1773266118580,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with primary biliary cholangitis (PBC) have decreased health\u2010related quality of life (HRQoL). Here, we investigate HRQoL in two cohorts of transplanted patients with PBC and compare their results to healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We used generic SF\u201036 and disease\u2010specific PBC\u201040 questionnaires to evaluate HRQoL in 26 patients with PBC (23 females, age 59.4\u00a0\u00b1\u00a05.7\u00a0years) before and after liver transplantation (LT), and in 107 patients with PBC (99 females, age 62.8\u00a0\u00b1\u00a06.7\u00a0years) who were previously transplanted. The control group was comprised of 60 healthy controls (55 females, age 54.6\u00a0\u00b1\u00a08.8\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Health\u2010related quality of life improved after LT in 85% of PBC patients. The SF\u201036 measure showed significant (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) improvements in the majority of domains after LT, and in the summary scores both physical and mental. We also documented significant improvements in pruritus and\u00a0fatigue after LT (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). However, liver graft recipients had significantly worse physical functioning, physical role, and emotional role domains, and physical component score (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), as compared to healthy subjects. No differences in HRQoL were detected between patients evaluated after short and prolonged post\u2010LT periods (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver transplantation substantially improves most aspects of life quality in PBC patients. Nevertheless, their HRQoL remains worse in comparison to healthy individuals, mainly in physical aspects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13434","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T11:49:04Z","timestamp":1540554544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of liver transplantation on health\u2010related quality of life in patients with primary biliary cholangitis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0113-0777","authenticated-orcid":false,"given":"Marcin","family":"Krawczyk","sequence":"first","affiliation":[{"name":"Department of Medicine II Saarland University Medical Center Homburg Germany"},{"name":"Laboratory of Metabolic Liver Diseases, Center for Preclinical Research, Department of General, Transplant and Liver Surgery Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Ko\u017ama","sequence":"additional","affiliation":[{"name":"Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Szyma\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Immunology, Transplantology and Internal Medicine, Transplantation Institute Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Leszko","sequence":"additional","affiliation":[{"name":"Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Przedniczek","sequence":"additional","affiliation":[{"name":"Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6613-7638","authenticated-orcid":false,"given":"Krzysztof","family":"Mucha","sequence":"additional","affiliation":[{"name":"Department of Immunology, Transplantology and Internal Medicine, Transplantation Institute Medical University of Warsaw Warsaw Poland"},{"name":"Institute of Biochemistry and Biophysics Polish Academy of Sciences Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Foroncewicz","sequence":"additional","affiliation":[{"name":"Department of Immunology, Transplantology and Internal Medicine, Transplantation Institute Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek","family":"P\u0105czek","sequence":"additional","affiliation":[{"name":"Department 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