{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:32:10Z","timestamp":1790235130562,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5U01-AI058013"],"award-info":[{"award-number":["5U01-AI058013"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5U19-AI070119"],"award-info":[{"award-number":["5U19-AI070119"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We performed a study to identify differences in the urinary microbiome associated with chronic allograft dysfunction (CAD) and compared the urinary microbiome of male and female transplant recipients with CAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2010control study enrolled 67 patients within the Deterioration of Kidney Allograft Function (DeKAF) Genomics cohort at two transplant centers. CAD was defined as a greater than 25% rise in serum creatinine relative to a 3\u00a0month post\u2010transplant baseline. Urine samples from patients with and without CAD were analyzed using 16S V4 bacterial ribosomal DNA sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Corynebacterium<\/jats:italic> was more prevalent in female and male patients with CAD compared to non\u2010CAD female patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0005). A total 21 distinct Operational Taxonomic Unit (OTUs) were identified as significantly different when comparing CAD and non\u2010CAD patients using Kruskal\u2010Wallis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). A subset analysis of female patients with CAD compared to non\u2010CAD females identified similar differentially abundant OTUs, including the genera <jats:italic>Corynebacterium<\/jats:italic> and <jats:italic>Staphylococcus<\/jats:italic> (Kruskal\u2010Wallis; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004, respectively). Male CAD vs female CAD analysis showed greater abundance of phylum <jats:italic>Proteobacteria<\/jats:italic> in males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were differences in the urinary microbiome when comparing female and male CAD patients with their female non\u2010CAD counterparts and these differences persisted in the subset analysis limited to female patients only.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13436","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T20:40:57Z","timestamp":1540845657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients"],"prefix":"10.1111","volume":"32","author":[{"given":"Jennifer F.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medicine, Nephrology Division Hennepin Healthcare Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amutha","family":"Muthusamy","sequence":"additional","affiliation":[{"name":"Hennepin Healthcare Research Institute Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel A.","family":"Al\u2010Ghalith","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biology University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Knights","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Biotechnology Institute University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Biostatistics University of Minnesota Minneapolis 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