{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:49:31Z","timestamp":1767973771217,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical significance of apoptosis in assessing the quality of donor liver grafts remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to determine whether apoptosis in a donor liver is predictive of early allograft dysfunction (EAD) and graft survival after liver transplantation (LT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Donor liver specimens were analyzed for apoptosis using TUNEL assays. The prognostic factors for EAD were identified through logistic regression analyses, and a nomogram was developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The apoptosis index of donor livers in EAD patients was significantly higher than that of donors livers in non\u2010EAD patients (median 5.3; interquartile range [IQR] 3.4 vs 3.5; 3.6, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Multivariate analyses identified the apoptosis index of the donor liver (HR\u00a0=\u00a06.927, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and five other characteristics as independent predictors of EAD. A nomogram built on these predictive variables showed good calibration and discriminatory abilities, with a c\u2010index value of 0.847. The 30\u2010day graft survival rates in the high apoptosis index (apoptosis index &gt;4.4%) group were significantly lower than those in the low apoptosis index (apoptosis index \u22644.4%) group (84.4% vs 97.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Donor liver apoptosis plays a significant role in predicting EAD after LT. Furthermore, a high apoptosis index in the donor liver was associated with inferior graft survival in the short\u2010term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13438","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T17:54:30Z","timestamp":1541094870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Donor liver apoptosis is associated with early allograft dysfunction and decreased short\u2010term graft survival after liver transplantation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-7604","authenticated-orcid":false,"given":"Zebin","family":"Zhu","sequence":"first","affiliation":[{"name":"Organ Transplant Center, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology Guangzhou China"},{"name":"Guangdong Provincial International Cooperation Base of Science and Technology Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhua","family":"Tang","sequence":"additional","affiliation":[{"name":"Organ Transplant Center, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology Guangzhou China"},{"name":"Guangdong Provincial International Cooperation Base of Science and Technology Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanzhou","family":"Huang","sequence":"additional","affiliation":[{"name":"Organ Transplant Center, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology Guangzhou China"},{"name":"Guangdong Provincial International Cooperation Base of Science and Technology Guangzhou 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