{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:09:37Z","timestamp":1781518177651,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1K08AI135078-01A1"],"award-info":[{"award-number":["1K08AI135078-01A1"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2013-23897-104604-23"],"award-info":[{"award-number":["2013-23897-104604-23"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["523-2014-2336"],"award-info":[{"award-number":["523-2014-2336"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["174111"],"award-info":[{"award-number":["174111"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["504881"],"award-info":[{"award-number":["504881"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rheumatic heart disease (RHD), an autoimmune sequela of Group A streptococcal infection, is a chronic valvular disease affecting 32 million people worldwide, predominantly in developing nations. As the predisposition to autoimmune sequela still remains post transplantation, our primary objective was to assess if there were differences in mortality and rejection rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Using the International Society for Heart and Lung Transplantation (ISHLT) adult heart transplant registry, we identified 42 RHD patients who had undergone heart transplantation between 1988 and 2014. We matched the 42 RHD recipients by transplant year, age, and gender to 420 dilated cardiomyopathy (DCM) recipients. One\u2010year mortality in the RHD group was 17.95% vs. 7.92% in the DCM group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07). Survival was significantly reduced in the RHD group vs. the DCM group via Kaplan Meier curves (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). In a multivariate model, RHD status (OR 3.19, 95% CI 1.15\u20108.83, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025) and serum creatinine (OR 1.41, 95% CI 1.09\u20101.82, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) were associated with an increased odds of one\u2010year mortality (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At one year post transplantation, RHD recipients had a significantly lower survival than DCM recipients. RHD status was also an independent predictor of mortality at 1\u00a0year post transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13439","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T16:25:47Z","timestamp":1541089547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Heart transplantation outcomes for rheumatic heart disease: Analysis of international registry data"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-0657","authenticated-orcid":false,"given":"Jennifer M.","family":"Dan","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health University of California  San Diego California"},{"name":"La Jolla Institute for Immunology  La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Silva Enciso","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of California San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1411-4482","authenticated-orcid":false,"given":"Lars H.","family":"Lund","sequence":"additional","affiliation":[{"name":"Departments of Medicine Karolinska Institutet Stockholm Sweden"},{"name":"Department of Cardiology Karolinska University Hospital Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Aslam","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health University of California  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70267-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000164"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007855"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.197-c1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-1606"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu449"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024769"},{"issue":"5","key":"e_1_2_9_9_1","first-page":"629","article-title":"Heart transplant in patients with predominantly rheumatic valvular heart disease.","volume":"24","author":"Rosa VE","year":"2015","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.08.017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.06.054"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318277e378"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4081\/pr.2012.e8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.128.5.1081"},{"issue":"8","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.4049\/jimmunol.143.8.2677","article-title":"Human and murine antibodies cross\u2010reactive with streptococcal M protein and myosin recognize the sequence GLN\u2010LYS\u2010SER\u2010LYS\u2010GLN in M protein","volume":"143","author":"Cunningham MW","year":"1989","journal-title":"J Immunol"},{"issue":"123","key":"e_1_2_9_16_1","first-page":"1119","article-title":"Serological evidence of immune priming by group A streptococci in patients with acute rheumatic fever","volume":"7","author":"Raynes JM","year":"2016","journal-title":"Front Microbiol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.05.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.006"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T06:43:28Z","timestamp":1694760208000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,22]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/ctr.13439"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13439","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,22]]},"assertion":[{"value":"2018-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13439"}}