{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:57:32Z","timestamp":1785373052770,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blood pressure variability and pulse pressure are strong and independent predictors of cardiovascular morbidity and mortality in the general population. So far, there are no data on the impact of blood pressure variability on mortality and graft survival after renal transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of 877 patients who underwent kidney transplantation between 1997 and 2011 in two transplant centers in Germany (Berlin and Bochum) with a follow\u2010up of 12\u2010266\u00a0months. Visit\u2010to\u2010visit blood pressure variability over the first 12\u00a0months after transplantation (3 visits) and during the first 120\u00a0months after transplantation (7 visits) was calculated as the coefficient of variation (CV = standard deviation (SD)\/mean blood pressure). Patient and graft survival was defined as composite endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cumulative survival was significantly higher for those patients with lower systolic blood pressure and pulse pressure within both the first 12\u00a0months and the 120\u00a0months posttransplant. After adjustment of data for gender, age, body mass index, and coronary artery disease, the cumulative incidence of the combined endpoint did not significantly differ between patients with lower vs higher CV (12\u00a0months CV hazard ratio (HR) (95% CI) = 0.90 (0.66\u20101.23), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.51; 120\u00a0months CV HR (95% CI)\u00a0=\u00a00.92 (0.67\u20101.26), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.60). A lower systolic blood pressure remained highly predictive for better survival in adjusted analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Visit\u2010to\u2010visit blood pressure variability is not associated with mortality or graft loss after kidney transplantation in this retrospective analysis. In analogy to the general population, however, there is an inverse relationship of survival and pulse pressure as a marker of arterial stiffness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13448","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T11:00:11Z","timestamp":1542193211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The impact of blood pressure variability and pulse pressure on graft survival and mortality after kidney transplantation"],"prefix":"10.1111","volume":"33","author":[{"given":"Nikolaos","family":"Pagonas","sequence":"first","affiliation":[{"name":"Universit\u00e4tsklinikum Marien Hospital Herne, Medizinische Klinik I Ruhr\u2010University of Bochum Bochum Germany"},{"name":"Department of Cardiology and Angiology Medical University Brandenburg Brandenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7784-2490","authenticated-orcid":false,"given":"Konstantinos","family":"Markakis","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Marien Hospital Herne, Medizinische Klinik I Ruhr\u2010University of Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Bauer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Marien Hospital Herne, Medizinische Klinik I Ruhr\u2010University of Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix S.","family":"Seibert","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Marien Hospital Herne, Medizinische Klinik I Ruhr\u2010University of Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Seidel","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Marien Hospital Herne, Medizinische Klinik I Ruhr\u2010University of Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Zidek","sequence":"additional","affiliation":[{"name":"Department of Nephrology Charit\u00e9 \u2013 Campus Benjamin Franklin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Kykalos","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery University Hospital Knappschaftskrankenhaus Bochum, Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Sasko","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Marien Hospital Herne, Medizinische Klinik I Ruhr\u2010University of Bochum Bochum Germany"},{"name":"Department of Cardiology and Angiology Medical University Brandenburg Brandenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klein","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Marien Hospital Herne, Medizinische Klinik I Ruhr\u2010University of Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Babel","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Marien Hospital Herne, Medizinische Klinik I Ruhr\u2010University of Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Viebahn","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery University Hospital Knappschaftskrankenhaus Bochum, Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm H.","family":"Westhoff","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Marien Hospital Herne, Medizinische Klinik I Ruhr\u2010University of Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03283.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00816.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200109271-00003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00573.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095676.90936.80"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60655-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.03.013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a76775"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01093.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.140798"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200312000-00012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60309-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.162255"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70066-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.6.539"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4891"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000431740.32696.cc"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00744.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01974-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.8.1672"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"issue":"3","key":"e_1_2_8_25_1","first-page":"iii3\u20108","article-title":"Cardiovascular risk factors in renal transplantation\u2013current controversies","volume":"21","author":"Marcen R","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09788"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.1999.130410.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001335"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T06:33:14Z","timestamp":1694673194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,6]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/ctr.13448"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13448","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,6]]},"assertion":[{"value":"2018-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13448"}}