{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:29:47Z","timestamp":1753878587609,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T00:00:00Z","timestamp":1547942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a prospective randomized controlled trial, between May 2001 and January 2003, 132 live\u2010donor kidney transplant recipients were randomized to receive sirolimus primary immunosuppression, either in combination with low dose tacrolimus (Tac group) or in combination with mycophenolate mofetil (<jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> group). We have previously reported on 2\u2010 and 5\u2010year follow\u2010up results, with favorable patient and graft outcomes obtained in both groups. In view of recent published reports of increased risk of inferior outcomes among sirolimus\u2010treated patients, we herein present results of an observational extension of the previously randomized patients 15\u00a0years post\u2010transplantation. Mortality rates were 10.8% and 3% in Tac and <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> groups respectively after mean follow\u2010up period of 11.2\u201011.8\u00a0years. Comparable graft survival rates were obtained in both groups ranging from 60% to 62.7%. The (<jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content>) group continued to have the advantage of remaining on primary plan of immunosuppression (56.7% of patients) as well as to maintain better graft function in terms of serum creatinine level. Herein, we presented longest term published data for sirolimus\u2010based immunosuppression among live\u2010donor kidney transplants with favorable outcome in terms of survival and graft function.<\/jats:p>","DOI":"10.1111\/ctr.13463","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T15:52:14Z","timestamp":1544716334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcome of sirolimus\u2010based immunosuppression, fifteen years post\u2013live\u2010donor kidney transplantation: Single\u2010center experience"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-4942","authenticated-orcid":false,"given":"Ahmed F","family":"Hamdy","sequence":"first","affiliation":[{"name":"Nephrology Division Urology and Nephrology Center Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed A","family":"Elhadedy","sequence":"additional","affiliation":[{"name":"Nephrology Division Urology and Nephrology Center Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed F","family":"Donia","sequence":"additional","affiliation":[{"name":"Nephrology Division Urology and Nephrology Center Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noheir M","family":"Taha","sequence":"additional","affiliation":[{"name":"Pathology Division Urology and Nephrology Center Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A","family":"Bakr","sequence":"additional","affiliation":[{"name":"Nephrology Division Urology and Nephrology Center Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02480-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200101270-00019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200004150-00009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200210270-00002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01064.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007091001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03826.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6679"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.21"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04281.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00190116"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14124"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001098"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04235.x"},{"issue":"4","key":"e_1_2_9_16_1","first-page":"283","article-title":"Proteinuria among primarily sirolimus treated live\u2010donor renal transplant recipients\u2019 long\u2010term experience","volume":"8","author":"Hamdy AF","year":"2010","journal-title":"Exp Clin Transplant"}],"container-title":["Clinical 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