{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:36:49Z","timestamp":1776951409117,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic right ventricular (RV) failure may progress necessitating referral for orthotropic heart transplantation (OHT). Pulmonary hypertension (PH) frequently coexists in adult congenital heart disease and can complicate the assessment for OHT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010center case series of six patients (median age 34.9\u00a0years [IQR, 31.9\u201042.4]) with systemic RV physiology with PH referred for OHT evaluation from 2008 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010third (n\u00a0=\u00a06) of 18 patients with systemic RV physiology referred for OHT evaluation had pulmonary arterial hypertension (PAH) defined as mean pulmonary artery pressure (mPAP)\u00a0&gt;\u00a025\u00a0mm Hg and pulmonary vascular resistance (PVR)\u00a0&gt;\u00a03 Wood Units. Two of the six patients were considered OHT\u2010ineligible due to PH and comorbidities. Of the remaining four, two had pre\u2010capillary PH and underwent heart\u2010lung transplant (HLTx). The other two demonstrated reversibility of PVR with vasodilator testing and underwent OHT alone, one of whom died post\u2010transplant from PH crisis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pulmonary arterial hypertension is common in systemic RV patients referred for OHT. Systemic RV dysfunction places these patients at risk for post\u2010capillary PH but pre\u2010capillary PH can exist. Despite management with selective pulmonary vasodilators and afterload reduction, criteria for listing patients for HLTx vs OHT are not known and need further elucidation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13496","type":"journal-article","created":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T06:28:07Z","timestamp":1550298487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pulmonary arterial hypertension in adults with systemic right ventricles referred for cardiac transplantation"],"prefix":"10.1111","volume":"33","author":[{"given":"Yuli Y.","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Division of Cardiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-5305","authenticated-orcid":false,"given":"Katherine","family":"Awh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Division of Cardiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Acker","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavan","family":"Atluri","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bermudez","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Crespo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Drajpuch","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Division of Cardiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhondalyn","family":"Forde\u2010Mclean","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Fuller","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery The Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Mazurek","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Mascio","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery The Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan N.","family":"Menachem","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Rame","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Ruckdeschel","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Division of Cardiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Tobin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Division of Cardiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Wald","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031544"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu102"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00682-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.135392"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.03.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.04.072"},{"issue":"8","key":"e_1_2_7_8_1","first-page":"596","article-title":"Heart or heart\u2010lung transplantation for patients with congenital heart disease in England","volume":"105","author":"Dimopoulos K","year":"2019","journal-title":"Heart"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.032"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.10.023"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.098848"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.03.033"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.006976"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(74)90096-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-009-9597-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.02.039"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00625-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006481"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00309-X"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.047"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.5.1037"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.09.017"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx034"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.009"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12387"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2012.01689.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90050-W"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.09.045"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.04.071"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.12.017"},{"issue":"4","key":"e_1_2_7_35_1","first-page":"971","article-title":"Reversibility of fixed pulmonary hypertension in left ventricular assist device support recipients","volume":"40","author":"Mikus E","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.07.012"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.07.107"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.03.003"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.03.005"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13496","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13496","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.13496","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T08:39:47Z","timestamp":1694335187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,5]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/ctr.13496"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13496","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,5]]},"assertion":[{"value":"2019-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13496"}}