{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:37:08Z","timestamp":1782459428867,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Strongyloides stercoralis<\/jats:italic> infects 100 million people worldwide. Mortality rates in hyperinfection syndrome exceed 50%. Donor\u2010derived <jats:italic>Strongyloides<\/jats:italic> infection has occurred after heart, kidney, kidney\u2010pancreas and liver transplantation; yet, only 10% of the US organ procurement organizations currently screen donors for strongyloidiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a fatal case of donor\u2010derived disseminated <jats:italic>Strongyloides<\/jats:italic> infection in a liver transplant recipient. Following this case, we implemented universal screening and treatment of donors and recipients. We reviewed our local epidemiology and outcomes after protocol implementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a total of 355 deceased donors accepted at our center between January 2016, and March 2018, 14 (3.9%) had positive <jats:italic>Strongyloides<\/jats:italic> serology. Except for the index case, all other recipients of <jats:italic>Strongyloides<\/jats:italic> antibody\u2010positive donors within that period (including 10 kidneys, 3 livers, one combined liver\/kidney, and one kidney\/pancreas from eight seropositive donors) received post\u2010transplant prophylaxis with ivermectin, and to date are alive and doing well without signs of infection. Between October 2015, and September 2016, a total of 441 deceased donor solid organ transplants were performed at our center. 220 of these recipients had pretransplant <jats:italic>Strongyloides<\/jats:italic> serology available, and 23 of them were seropositive (10.5%). Within the first two years after the implementation of universal screening and treatment of donors and recipients, we had no cases of <jats:italic>Strongyloides<\/jats:italic> reactivation in our center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Implementation of a <jats:italic>Strongyloides<\/jats:italic> screening and treatment protocol in our center was an effective strategy to prevent both recipient\u2010 and donor\u2010derived strongyloidiasis. Transplant centers should consider implementation of <jats:italic>Strongyloides<\/jats:italic> preventive strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13497","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T04:34:40Z","timestamp":1550464480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Implementation of a <i>Strongyloides<\/i> screening strategy in solid organ transplant donors and recipients"],"prefix":"10.1111","volume":"33","author":[{"given":"Jose F.","family":"Camargo","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine University of Miami Miller School of Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9626-0760","authenticated-orcid":false,"given":"Jacques","family":"Simkins","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine University of Miami Miller School of Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-1163","authenticated-orcid":false,"given":"Shweta","family":"Anjan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine University of Miami Miller School of Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Guerra","sequence":"additional","affiliation":[{"name":"Miami Transplant Institute Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Vianna","sequence":"additional","affiliation":[{"name":"Miami Transplant Institute Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Salama","sequence":"additional","affiliation":[{"name":"Life Alliance Organ Recovery Agency Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Albright","sequence":"additional","affiliation":[{"name":"Miami Transplant Institute Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shipman","sequence":"additional","affiliation":[{"name":"Miami Transplant Institute Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Montoya","sequence":"additional","affiliation":[{"name":"Miami Transplant Institute Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele I.","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine University of Miami Miller School of Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian M.","family":"Abbo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine University of Miami Miller School of Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.04.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002640"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02700.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002214"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2009.02.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/630201"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182115b7b"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13137"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.08.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12865"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.11-0214"},{"key":"e_1_2_6_13_1","unstructured":"AnjanS Doblecki\u2010LewisS SimkinsJ LichtenbergerP.Strongyloidiasis in Solid Organ Transplant Candidates: Demographics of Patients screened at a Large Academic Center in the United States. 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