{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:32:59Z","timestamp":1781775179211,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of a 64\u2010year\u2010old woman who developed transfusion\u2010dependent anemia after cardiac transplantation, the etiology of which was unknown after initial comprehensive evaluation. At the suggestion of the Transplant Infectious Diseases consultant, microbial agents with red blood cell tropism pertinent to this patient such as Parvovirus B 19 (B19V) were investigated. The B19V viral load by PCR in peripheral blood was &gt;100\u00a0000\u00a0000 copies\/ml and after treatment with intravenous immunoglobulin (IVIG), her anemia resolved. Here, we summarize the clinical and virologic characteristics, treatment, and outcome of fifteen cases of B19V\u2010induced anemia in heart transplant recipients. Spontaneous recovery from anemia secondary to B19V has also been reported in some heart transplant recipients, possibly due to an absence of their B19V P\u2010antigen receptor and\/or reduction in their immunosuppression. Therefore, in heart transplant patients, B19V should be suspected early as a cause of severe anemia of unknown etiology. The extent that B19V\u2010induced anemia is underdiagnosed in heart transplant recipients is unknown.<\/jats:p>","DOI":"10.1111\/ctr.13498","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T14:20:16Z","timestamp":1550499616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Parvovirus B19\u2010induced severe anemia in heart transplant recipients: Case report and review of the literature"],"prefix":"10.1111","volume":"33","author":[{"given":"Natalia C.","family":"Pinto","sequence":"first","affiliation":[{"name":"Department of Medicine and Division of Infectious Diseases and Geographic Medicine Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Medicine and Division of Infectious Diseases and Geographic Medicine Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5486-5710","authenticated-orcid":false,"given":"Carlos A.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Medicine and Division of Infectious Diseases and Geographic Medicine Stanford University School of Medicine Stanford California"},{"name":"Palo Alto Medical Foundation Toxoplasma Serology Laboratory Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran K.","family":"Khush","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Stanford University School of Medicine Stanford California"},{"name":"Department of Medicine, Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-7393","authenticated-orcid":false,"given":"Yasbanoo","family":"Moayedi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support Stanford University Stanford California"},{"name":"Ted Rogers Centre of Excellence for Heart Research, Peter Munk Cardiac Centre University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Department of Heart and Lung Transplantation Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Teuteberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Stanford University School of Medicine Stanford California"},{"name":"Department of Medicine, Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G.","family":"Montoya","sequence":"additional","affiliation":[{"name":"Department of Medicine and Division of Infectious Diseases and Geographic Medicine Stanford University School of Medicine Stanford California"},{"name":"Palo Alto Medical Foundation Toxoplasma Serology Laboratory Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.485-505.2002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb04276.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3738514"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0536"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2006.17.909"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199310000-00011"},{"issue":"8","key":"e_1_2_6_8_1","first-page":"843","article-title":"Transient aplastic anemia caused by parvovirus B19 infection in a heart transplant recipient","volume":"15","author":"Bergen GA","year":"1996","journal-title":"J Heart Lung 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