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This updated guideline from the American Society of Transplantation Infectious Diseases Community of Practice provides evidence\u2010based and expert recommendations for screening, diagnosis, prevention, and treatment of CMV in solid organ transplant recipients. CMV serology to detect immunoglobulin G remains as the standard method for pretransplant screening of donors and transplant candidates. Antiviral prophylaxis and preemptive therapy are the mainstays of CMV prevention. The lack of a widely applicable viral load threshold for diagnosis and preemptive therapy is highlighted, as a result of variability of CMV nucleic acid testing, even in the contemporary era when calibrators are standardized. Valganciclovir and intravenous ganciclovir remain as drugs of choice for CMV management. Strategies for managing drug\u2010resistant CMV infection are presented. There is an increasing use of CMV\u2010specific cell\u2010mediated immune assays to stratify the risk of CMV infection after solid organ transplantation, but their role in optimizing CMV prevention and treatment efforts has yet to be demonstrated. Specific issues related to pediatric transplant recipients are discussed.<\/jats:p>","DOI":"10.1111\/ctr.13512","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T18:21:58Z","timestamp":1551378118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":723,"title":["Cytomegalovirus in solid organ transplant recipients\u2014Guidelines of the American Society of Transplantation Infectious Diseases Community of Practice"],"prefix":"10.1111","volume":"33","author":[{"given":"Raymund R.","family":"Razonable","sequence":"first","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Humar","sequence":"additional","affiliation":[{"name":"University Health Network Toronto Ontario Canada"},{"name":"Transplant Institute University of Toronto Toronto Ontario 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