{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:13:04Z","timestamp":1792271584869,"version":"4.4.0"},"reference-count":112,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T00:00:00Z","timestamp":1555200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005160","name":"American Society of Transplantation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of cryptococcosis in the pre\u2010 and post\u2010transplant period. The current update now includes a discussion of cryptococcosis, which is the third most common invasive fungal infection in SOT recipients. Infection often occurs a year after transplantation; however, early infections occur and donor\u2010derived infections have been described within 3\u00a0months after transplant. There are two main species that cause infection,\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    and\n                    <jats:italic>C\u00a0gattii.<\/jats:italic>\n                    Clinical onset may be insidious, but headaches, fevers, and mental status changes should warrant diagnostic testing. The lateral flow cryptococcal antigen assay is now the preferred test from serum and cerebrospinal fluid due to its rapidity, accuracy, and cost. A lumbar puncture with measurement of opening pressure is recommended for patients with suspected or proven cryptococcosis. Lipid amphotericin B plus 5\u2010flucytosine is used as initial treatment of meningitis, disseminated infection, and moderate\u2010to\u2010severe pulmonary infection, followed by fluconazole as consolidation therapy. Fluconazole is effective for mild\u2010to\u2010moderate pulmonary infection. Immunosuppression reduction as part of management may lead to immune reconstitution syndrome that may resemble active disease.\n                  <\/jats:p>","DOI":"10.1111\/ctr.13543","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T03:44:42Z","timestamp":1553226282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":140,"title":["Cryptococcosis in solid organ transplantation\u2014Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice"],"prefix":"10.1111","volume":"33","author":[{"given":"John W.","family":"Baddley","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham and Birmingham VA Medical Center Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme N.","family":"Forrest","sequence":"additional","affiliation":[{"name":"VA Portland Healthcare System Portland 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