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Time from transplant to diagnosis of invasive aspergillosis (IA) is variable, but most cases present within the first year post\u2010transplant, with shortest time to onset among liver and heart transplant recipients. The overall 12\u2010week mortality of IA in SOT exceeds 20%; prognosis is worse among those with central nervous system involvement or disseminated disease. Bronchoalveolar lavage galactomannan is preferred for the diagnosis of IA in lung and non\u2010lung transplant recipients, in combination with other diagnostic modalities (eg, chest CT scan, culture). Voriconazole remains the drug of choice to treat IA, with isavuconazole and lipid formulations of amphotericin B regarded as alternative agents. The role of combination antifungals for primary therapy of IA remains controversial. Either universal prophylaxis or preemptive therapy is recommended in lung transplant recipients, whereas targeted prophylaxis is favored in liver and heart transplant recipients. In these guidelines, we also discuss newer antifungals and diagnostic tests, antifungal susceptibility testing, and special patient populations.<\/jats:p>","DOI":"10.1111\/ctr.13544","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T06:29:46Z","timestamp":1553236186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":279,"title":["Invasive Aspergillosis in solid\u2010organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-5229","authenticated-orcid":false,"given":"Shahid","family":"Husain","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Multi\u2010Organ Transplant Unit University Health Network, University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-5011","authenticated-orcid":false,"given":"Jose F.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases University of Miami Miller School of Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu337"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0808853"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/651262"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.08.003"},{"issue":"3","key":"e_1_2_11_6_1","first-page":"269","article-title":"Epidemiological features of invasive mold infections among solid organ transplant recipients: PATH Alliance\u00ae registry analysis","volume":"55","author":"Husain S","year":"2017","journal-title":"Med Mycol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/430602"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199903000-00003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199602270-00029"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02114892"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.6.1379"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/429329"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03548.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1161"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/345441"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.36239"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12129"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.1.44-69.2005"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200104150-00016"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21099"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199709150-00009"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1997.01430270090019"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000202421.94822.f7"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540110077470"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000189282"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198311000-00011"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.2.230"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198211000-00002"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1975.00330090035004"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2017.06.016"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000055983.69730.ED"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01548.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12691"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00492.x"},{"issue":"1","key":"e_1_2_11_35_1","first-page":"112","article-title":"Prevalence and outcome of invasive fungal infections in 1,963 thoracic organ transplant recipients: a multicenter retrospective study. 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