{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:45:17Z","timestamp":1791488717317,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012444","name":"Telfer School of Management, University of Ottawa","doi-asserted-by":"publisher","award":["University of Ottawa Developmental Research Grant"],"award-info":[{"award-number":["University of Ottawa Developmental Research Grant"]}],"id":[{"id":"10.13039\/100012444","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polyvalent immunoglobulin is commonly used for desensitization and treatment of antibody\u2010mediated rejection in kidney transplantation but its impact on other outcomes is not known. This systematic review investigated the impact of immunoglobulin prophylaxis on infection, rejection, graft loss, and death following kidney transplantation. A comprehensive literature search located 18 studies (n\u00a0=\u00a08 randomized controlled trials). None examined the effect of immunoglobulin prophylaxis in transplant recipients with hypogammaglobulinemia. Quality of included studies was variable with high to very high risk of bias. In the randomized trials, immunoglobulin use did not reduce cytomegalovirus infection (OR 0.68 [0.39, 1.21]; 6 studies, n\u00a0=\u00a0295), rejection (OR 0.96 [0.50, 1.82]; 4 studies, n\u00a0=\u00a0187), or graft loss (OR 1.03 [0.46, 2.30]; 6 studies, n\u00a0=\u00a0265). In non\u2010randomized studies, immunoglobulin did not reduce cytomegalovirus infection (OR 0.63 [0.20, 1.94]; 6 studies, n\u00a0=\u00a0361) or death (OR 1.32 [0.05, 38.79]; 3 studies, n\u00a0=\u00a0222) but reduce rejection (OR 0.47 [0.24, 0.94]; 4 studies, n\u00a0=\u00a0268) and graft loss (OR 0.15 [0.05, 0.43]; 2 studies, n\u00a0=\u00a0118). Data were scarce and sample size of current evidence was small. Adequately powered randomized trials are needed to determine if immunoglobulin is an effective intervention to reduce infection, rejection, graft loss, or death following kidney transplantation with and without hypogammaglobulinemia.<\/jats:p>","DOI":"10.1111\/ctr.13560","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T17:27:35Z","timestamp":1554226055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical outcomes of polyvalent immunoglobulin use in solid organ transplant recipients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-218X","authenticated-orcid":false,"given":"Samuel","family":"Bourassa\u2010Blanchette","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg A.","family":"Knoll","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"},{"name":"Division of Nephrology, Department of Medicine Renal Transplantation, University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hutton","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Fergusson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Bennett","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Tay","sequence":"additional","affiliation":[{"name":"Blood and Marrow Transplant Program Alberta Health Sciences Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. William","family":"Cameron","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"},{"name":"Division of Infectious Diseases, Department of Medicine University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-5109","authenticated-orcid":false,"given":"Juthaporn","family":"Cowan","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine University of Ottawa Ottawa Ontario Canada"},{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"},{"name":"Division of Infectious Diseases, Department of Medicine University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12458"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.178"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2007.00556.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04192.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12401"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e3283186bbc"},{"issue":"1","key":"e_1_2_7_8_1","first-page":"622","article-title":"Humoral Immunity after kidney transplantation: impact of two randomized immunosuppressive protocols","volume":"18","author":"Legris T","year":"2013","journal-title":"Ann Transplant"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00425.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199911270-00012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200101270-00013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000543104.15192.10"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra993360"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.09.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-015-0156-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_7_18_1","unstructured":"TerminologyC.Criteria for Adverse Events (CTCAE) v5.0.https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_8.5x11.pdf. 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