{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:00:25Z","timestamp":1773054025877,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Persons with multiple sclerosis are increasingly treated with intermediate\u2010 or high\u2010dose chemotherapy and a hematopoietic cell autotransplant. This is often done in an inpatient setting using frozen blood cell grafts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Determine if chemotherapy and a hematopoietic cell autotransplant can be safely done in an outpatient setting using refrigerated, non\u2010frozen grafts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed an autotransplant protocol actionable in an outpatient setting using a refrigerated, non\u2010frozen blood graft collected after giving cyclophosphamide, 50\u00a0mg\/kg\/d\u00a0\u00d7\u00a02\u00a0days and filgrastim, 10\u00a0\u03bcg\/kg\/d. A second identical course was given 9\u00a0days later followed by infusion of blood cells stored at 4\u00b0C for 1\u20104\u00a0days. The co\u2010primary outcomes were rates of granulocyte and platelet recovery and therapy\u2010related mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We treated 426 consecutive subjects. Median age was 47\u00a0years (range, 21\u201068\u00a0years). A total of 145 (34%) were male. Median graft refrigeration time was 1\u00a0day (range, 1\u20104\u00a0days). Median interval to granulocytes &gt;0.5\u00a0\u00d7\u00a010E\u00a0+\u00a09\/L was 8\u00a0days (range, 2\u201012) and to platelets &gt;20\u00a0\u00d7\u00a010E\u00a0+\u00a09\/L, 8\u00a0days (range, 1\u201012). Only 15 subjects (4%) were hospitalized, predominately for iatrogenic pneumothorax (N\u00a0=\u00a05) and neutropenic fever (N\u00a0=\u00a04). There was only 1 early death from infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intermediate\u2010dose chemotherapy and a hematopoietic cell autotransplant can be safely done in an outpatient setting using, refrigerated, non\u2010frozen grafts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13567","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T14:53:02Z","timestamp":1555771982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Determine safety of outpatient chemotherapy and autotransplants using refrigerated, non\u2010frozen grafts in persons with multiple sclerosis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-1676","authenticated-orcid":false,"given":"Robert Peter","family":"Gale","sequence":"first","affiliation":[{"name":"Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-4861","authenticated-orcid":false,"given":"Gisela Berenice","family":"G\u00f3mez\u2010Cruz","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna de Puebla Puebla M\u00e9xico"},{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Olivares\u2010Gazca","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna de Puebla Puebla M\u00e9xico"},{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s A.","family":"Le\u00f3n\u2010Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna de Puebla Puebla M\u00e9xico"},{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"G\u00f3mez\u2010Almaguer","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"G\u00f3mez\u2010De\u2010Le\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u00edas Eugenio","family":"Gonz\u00e1lez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Ruiz\u2010Arg\u00fcelles","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna de Puebla Puebla M\u00e9xico"},{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla Puebla M\u00e9xico"},{"name":"Laboratorios Ruiz Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Soto\u2010Vega","sequence":"additional","affiliation":[{"name":"Universidad An\u00e1huac Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Mu\u00f1oz\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Universidad An\u00e1huac Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo Jos\u00e9","family":"Ruiz\u2010Delgado","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna de Puebla Puebla M\u00e9xico"},{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla Puebla M\u00e9xico"},{"name":"Laboratorios Ruiz Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo Jos\u00e9","family":"Ruiz\u2010Arg\u00fcelles","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna de Puebla Puebla M\u00e9xico"},{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla Puebla M\u00e9xico"},{"name":"Laboratorios Ruiz Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2015.01.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000469655"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.03.012"},{"key":"e_1_2_6_5_1","first-page":"134","article-title":"Guidelines of the Brazilian Society of Bone Marrow Transplantation on hematopoietic stem cell multiple sclerosis","volume":"35","author":"Oliveira\u2010Rodriguez MA","year":"2013","journal-title":"Rev Bras Hematol Hemoter"},{"key":"e_1_2_6_6_1","first-page":"1","article-title":"NEDA status in highly active MS can be more easily obtained with autologous hematopoietic stem cell transplantation than other drugs","author":"Sormani MP","year":"2016","journal-title":"Mult Scler"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.12.067"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18743"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V71.3.723.723"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000455"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003987"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5867"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.17986"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.03.016"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-012-0162-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmy028"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.71"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-017-0047-7"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.13567","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T20:21:52Z","timestamp":1694377312000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,7]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/ctr.13567"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13567","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,7]]},"assertion":[{"value":"2019-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13567"}}