{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:54:28Z","timestamp":1788990868943,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis C (HCV) disease transmission from the use of HCV antibody\u2010positive and HCV nucleic acid test\u2010negative (HCV Ab+\/NAT\u2212) kidneys have been anecdotally reported to be absent. We prospectively analyzed kidney transplant (KT) outcomes from HCV Ab+\/NAT\u2212 donors to HCV na\u00efve recipients under T\u2010cell depleting early steroid withdrawal immunosuppression. Allografts from 40 HCV Ab+\/NAT\u2212 donors were transplanted to 52 HCV Ab\u2212 recipients between July 2016 and February 2018. Thirty\u2010three (82.5%) of donors met Public Health Service (PHS) increased risk criteria. De novo HCV infection was detected at 3\u00a0months post\u2010KT in one recipient (1.9%). This was a case of transmission from a HCV Ab+ NAT+ donor with an initial false\u2010negative NAT completed using sample collected on donor hospital admission (day 2). At the time of HCV diagnosis, a stored donor sample collected during procurement (day 4) was tested and resulted NAT\u2010positive. Subsequently, sustained virologic response (SVR) was achieved with 12\u00a0weeks of glecaprevir\/pibrentasvir. One death with functioning graft at 261\u00a0days post\u2010KT was determined not related to HCV or donor factors. This experience provides evidence of a low transmission rate of HCV from HCV Ab+\/ NAT\u2212 kidney donors, thereby arguing for increasing utilization.<\/jats:p>","DOI":"10.1111\/ctr.13598","type":"journal-article","created":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T00:23:41Z","timestamp":1558225421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Use of HCV Ab+\/NAT\u2212 donors in HCV na\u00efve renal transplant recipients to expand the kidney donor pool"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3457-1568","authenticated-orcid":false,"given":"Ann","family":"Dao","sequence":"first","affiliation":[{"name":"University of Cincinnati College of Medicine Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Cuffy","sequence":"additional","affiliation":[{"name":"The Christ Hospital Cincinnati 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