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This study evaluated the prevalence of AD in lung transplant (LTx) candidates, its determinants, prognostic implications, and prevalence post\u2010transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective one\u2010year study of 103 LTx candidates with AD assessed using heart rate (HR) from the six\u2010minute walk test (6MWT). Impaired chronotropic response index (CRI) was defined as &lt;80% age\u2010adjusted HR during 6MWT. Abnormal HR recovery (HRR) was categorized as reduction in HR\u00a0\u2264\u00a012 beats\/minute after the first minute of 6MWT cessation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abnormal CRI and HRR were observed in 94% and 76% of patients, respectively. A lower CRI was associated with obstructive lung disease and lower estimated aerobic capacity. CRI was independently associated with 6MW distance [12\u00a0m per 10% CRI, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03], but not with post\u2010transplant cardiovascular events, hospital stay, or one\u2010year mortality. At 3\u00a0months post\u2010transplant, no improvement was observed in CRI (99%, n\u00a0=\u00a066\/67, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.25) or HRR (88%, n\u00a0=\u00a036\/41, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.12).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cardiac AD was prevalent in LTx candidates and recipients, with chronotropic incompetence a modest contributor to exercise intolerance pretransplant. Further study may help determine whether direct autonomic measures such as HR variability may be more prognostic of LTx outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13612","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T14:14:17Z","timestamp":1558966457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impaired cardiac autonomic response in lung transplant patients: A retrospective cohort study"],"prefix":"10.1111","volume":"33","author":[{"given":"Vanessa","family":"Martelli","sequence":"first","affiliation":[{"name":"Department of Medicine, Respirology University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5564-9796","authenticated-orcid":false,"given":"Sunita","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Wickerson","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Toronto Toronto Ontario Canada"},{"name":"Lung Transplant Program University Health Network Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaya","family":"Gottesman","sequence":"additional","affiliation":[{"name":"Lung Transplant Program University Health Network Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Helm","sequence":"additional","affiliation":[{"name":"Lung Transplant Program University Health Network Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-8676","authenticated-orcid":false,"given":"Lianne G.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Respirology University of Toronto Toronto Ontario Canada"},{"name":"Lung Transplant Program University Health Network Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8786-9152","authenticated-orcid":false,"given":"Dmitry","family":"Rozenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Respirology University of Toronto Toronto Ontario Canada"},{"name":"Lung Transplant Program University Health Network Toronto Ontario Canada"},{"name":"Toronto General Hospital Research Institute Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.08.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2017.07.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12926"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-013-9544-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0287-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4065\/77.1.45"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2010.01877.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201105-0848OC"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.11.012"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.04.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479972313493097"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910283411804"},{"issue":"1","key":"e_1_2_9_14_1","first-page":"I77","article-title":"Autonomic nervous system and sudden cardiac death. 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