{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:53:32Z","timestamp":1776704012861,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["R38OT22183"],"award-info":[{"award-number":["R38OT22183"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008169","name":"Minneapolis Medical Research Foundation","doi-asserted-by":"publisher","award":["HHSH250201000018C"],"award-info":[{"award-number":["HHSH250201000018C"]}],"id":[{"id":"10.13039\/100008169","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Delayed graft function (DGF) in kidney transplant significantly increases inpatient and outpatient cost. Targeted, mild hypothermia in organ donors after neurologic determination of death significantly reduced the rate of DGF in a recent randomized controlled clinical trial. To assess the potential economic benefit of national implementation of donor hypothermia, rates of reduction DGF were combined with estimates of the impact of DGF on hospital cost and total health expenditure for standard and extended criteria donor organs (SCD and ECD). DGF increases the cost of the transplant episode by $9487 for ECD transplant and $10\u00a0342 for SCD transplant. Medicare recipients with DGF incur an additional $18\u00a0513 spending for ECD and $14\u00a0948 in SCD transplants over the first year. An absolute reduction in DGF rate after kidney transplantation consistent with trial results (ECD 25%, SCD 7%) has the potential to lower annual hospital cost for kidney transplant by $13\u00a0178\u00a0746 and annual Medicare spending by $20\u00a0970\u00a0706 compared to standard donor management practice using static cold storage. Targeted mild hypothermia improves care of renal transplant patients by safely reducing DGF rates in both ECD and SCD transplant. Broader application of this safe, effective, and low\u2010cost intervention could reduce healthcare expenditures for providers and insurers.<\/jats:p>","DOI":"10.1111\/ctr.13626","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T17:18:03Z","timestamp":1559668683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Modeling the economic benefit of targeted mild hypothermia in deceased donor kidney transplantation"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5684-0613","authenticated-orcid":false,"given":"David A.","family":"Axelrod","sequence":"first","affiliation":[{"name":"Department of Transplantation and HPB Surgery University of Iowa Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Malinoski","sequence":"additional","affiliation":[{"name":"Section of Surgical Critical Care VA Portland Health Care System (VAPORHCS) Portland Oregon"},{"name":"Division of Trauma, Critical Care, and Acute Care Surgery Oregon Health &amp; Science University Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhukar S.","family":"Patel","sequence":"additional","affiliation":[{"name":"Section of Surgical Critical Care VA Portland Health Care System (VAPORHCS) Portland Oregon"},{"name":"Department of Surgery Massachusetts General Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Broglio","sequence":"additional","affiliation":[{"name":"Berry Consultants, LLC Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Lewis","sequence":"additional","affiliation":[{"name":"Berry Consultants, LLC Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahnee","family":"Groat","sequence":"additional","affiliation":[{"name":"Division of Trauma, 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