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PTLD are a heterogeneous spectrum of predominantly B\u2010cell disorders, often extra\u2010nodal, with complex distinct pathogeneses and variable clinical presentations determined by pathologic subtype. Recent epidemiologic studies report a decrease in early EBV\u2010positive (+) PTLD and an increase in late EBV\u2010negative (\u2212) PTLD. Pre\u2010transplant EBV\u2010seronegativity and primary EBV infection, often from donor\u2010transmitted infection, are an important risk factors for EBV syndromes and early EBV\u00a0+\u00a0PTLD. Low\u2010quality evidence supports preemptive prevention strategies for early EBV\u00a0+\u00a0PTLD in EBV\u2010seronegative recipients that involve EBV DNA measurement in peripheral blood using assays requiring further result harmonization, combined with interventions to lower viral load. Reduction in immunosuppression (RIS) is the best validated intervention. WHO pathology classification of a tissue biopsy remains the gold standard for PTLD diagnosis; optimal staging procedures are uncertain. Treatment of CD20\n                    <jats:sup>+<\/jats:sup>\n                    PTLD with the response\u2010dependent sequential use of RIS, rituximab, and cytotoxic chemotherapy is recommended. Evidence gaps requiring future research and alternate treatment strategies including immunotherapy are highlighted.\n                  <\/jats:p>","DOI":"10.1111\/ctr.13652","type":"journal-article","created":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T07:33:50Z","timestamp":1561275230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":358,"title":["Post\u2010transplant lymphoproliferative disorders, Epstein\u2010Barr virus infection, and disease in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2326-7731","authenticated-orcid":false,"given":"Upton D.","family":"Allen","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Hospital for Sick Children University of Toronto Toronto ON Canada"},{"name":"Research 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