{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:20:54Z","timestamp":1784996454312,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The evolution of\u00a0trabecular bone score (TBS) and bone mineral density (BMD) over the first 5\u00a0years after renal transplantation was prospectively evaluated in 164 patients. Dual energy X\u2010ray absorptiometry (DXA) scans were performed at 0, 6, 12, 24, and 60\u00a0months. Cumulative steroid dose, serum 25(OH)D, calcium, parathyroid hormone, and total ALP levels at these time points were checked. Incident fractures were identified from X\u2010rays\/vertebral fracture assessments. Mean (SD) age, TBS, and lumbar spine BMD at baseline were 47.11 (9.53), 1.424 (0.097), and 0.935 (0.183) gm\/cm<jats:sup>2<\/jats:sup>, respectively. Baseline TBS was lower in tertiary 1.38 (0.07) vs secondary hyperparathyroidism 1.43 (0.01) vs post\u2010parathyroidectomy 1.46 (0.11); <jats:italic>P<\/jats:italic>\u00a0=\u00a0.035. Trabecular bone score and BMD significantly decreased from baseline\u2010&gt;6\u00a0months, changes after that at consecutive time points were non\u2010significant. 11% had incident fractures during the follow\u2010up period, majority being metatarsal with no vertebral or hip fractures noted. This first prospective evaluation of TBS and BMD evolution at multiple time points over 5\u00a0years suggest that microarchitectural and bone density deteriorations post\u2010renal transplantation stabilize after 6\u00a0months. Stabilization of these parameters could partially account for the absence of major fractures noted in this Asian population. Possible genetic and ethnic differences in fracture risk between Asian and Caucasian renal transplant patients have to be explored through large population\u2010based studies.<\/jats:p>","DOI":"10.1111\/ctr.13671","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T05:43:16Z","timestamp":1563860596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Addressing bone quality and bone density after renal transplantation: A prospective evaluation of the evolution of trabecular bone score and bone mineral density over the first 5\u00a0years following renal transplantation in Asian patients"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-8443","authenticated-orcid":false,"given":"Manju","family":"Chandran","sequence":"first","affiliation":[{"name":"Osteoporosis and Bone Metabolism Unit, Department of Endocrinology, Renal Transplant Osteoporosis Clinic Singapore General Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hao","sequence":"additional","affiliation":[{"name":"Division of Medicine, Health Services Research Unit (HSRU) Singapore General Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Kerwen","family":"Kwee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Singapore General Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du Soon","family":"Swee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Singapore General Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Chee Eng","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging Singapore General Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence Yi Shern","family":"Kee","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Singapore General Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushan","family":"Bharadwaj","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging Singapore General Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200208270-00011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.3014"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"410","article-title":"Fractures in kidney transplant recipients: a comparative study between England and New York State","volume":"16","author":"Arnold 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