{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:56:20Z","timestamp":1787165780457,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL116656"],"award-info":[{"award-number":["K23HL116656"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL121406"],"award-info":[{"award-number":["K23HL121406"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24HL115354"],"award-info":[{"award-number":["K24HL115354"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL087115"],"award-info":[{"award-number":["R01HL087115"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK097307"],"award-info":[{"award-number":["K23DK097307"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK111638"],"award-info":[{"award-number":["R01DK111638"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prior studies of post\u2013lung transplant acute kidney injury (AKI) have not accounted for confounding effects of primary graft dysfunction (PGD). We sought to test the impact of PGD on AKI risk factors and on the association of AKI with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included patients transplanted at the University of Pennsylvania from 2005\u201012, defined AKI using consensus criteria during transplant hospitalization, and defined PGD as grade 3 at 48\u201072\u00a0hours. We used multivariable logistic regression to test the impact of PGD on AKI risk factors and Cox models to test association of AKI with one\u2010year mortality adjusting for PGD and other confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 299 patients, 188 (62.9%) developed AKI with 142 (75%) cases occurring by postoperative day 4. In multivariable models, PGD was strongly associated with AKI (OR 3.76, 95% CI 1.72\u20108.19,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) but minimally changed associations of other risk factors with AKI. Both AKI (HR 3.64, 95% CI 1.68\u20107.88,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) and PGD (HR 2.55, 95% CI 1.40\u20104.64,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002) were independently associated with one\u2010year mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Post\u2013lung transplant AKI risk factors and association of AKI with mortality were independent of PGD. AKI may therefore be a target for improving lung transplant mortality rather than simply an epiphenomenon of PGD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.13678","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T11:04:17Z","timestamp":1564398257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The association of post\u2013lung transplant acute kidney injury with mortality is independent of primary graft dysfunction: A cohort study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-3418","authenticated-orcid":false,"given":"Michael G. S.","family":"Shashaty","sequence":"first","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin M.","family":"Forker","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Miano","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qufei","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Oyster","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Porteous","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Edward E.","family":"Cantu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Christie","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu226"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.08.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00867.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201210-1865OC"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04800512"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivy355"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01276.x"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"1","article-title":"Kidney disease: Improving global outcomes (KDIGO) acute kidney injury work group. 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