{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:48:03Z","timestamp":1776815283677,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T00:00:00Z","timestamp":1567900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is no recommendation regarding the type of induction therapy to use in ABO\u2010incompatible (ABOi) kidney transplantation. The aim of this retrospective study was to compare the outcome of ABOi living donor kidney transplant (LDKT) recipients who received either polyclonal antibodies or anti\u2010interleukin\u20102 receptor (IL\u20102R) blockers as an induction agent. All ABOi HLA\u2010compatible patients that received a LDKT between 03\/11 and 03\/18 in three French transplantation center (Paris Saint\u2010Louis, Paris Necker, and Toulouse) were included in the study. Fifty\u2010eight patients were given polyclonal antibodies and 39 patients received anti\u2010IL\u20102R blockers. We identified by a Cox proportional hazard model the use of polyclonal antibodies as a protective factor against acute rejection (HR\u00a0=\u00a00.4, 95%CI [0\u20100.9], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). However, pathological findings on protocol biopsies at 1\u00a0year were similar in both groups, as were patient and graft survivals, renal function, and complications. We conclude that the acute rejection rate was significantly higher in patients given anti\u2010IL\u20102R blockers compared to polyclonal antibodies. However, in our series, there was no negative impact on mid\u2010term outcome.<\/jats:p>","DOI":"10.1111\/ctr.13681","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T13:50:35Z","timestamp":1564667435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti\u2010IL\u20102R blockers comparing with polyclonal antibodies: Higher risk of rejection without negative mid\u2010term outcomes after ABO\u2010incompatible kidney transplantation"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3115-868X","authenticated-orcid":false,"given":"Arnaud","family":"Del Bello","sequence":"first","affiliation":[{"name":"Department of Nephrology and Organ Transplant CHU Rangueil Toulouse France"},{"name":"Universit\u00e9 Paul Sabatier Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3450-0033","authenticated-orcid":false,"given":"Gillian","family":"Divard","sequence":"additional","affiliation":[{"name":"Paris Translational Research Center for Organ Transplantation Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Belliere","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplant CHU Rangueil Toulouse France"},{"name":"Universit\u00e9 Paul Sabatier Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Congy\u2010Jolivet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"Molecular Immunogenetics Laboratory, EA 3034, Facult\u00e9 de M\u00e9decine Purpan IFR150 (INSERM) Toulouse France"},{"name":"Department of Immunology, H\u00f4pital de Rangueil CHU de Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Lanfranco","sequence":"additional","affiliation":[{"name":"Department of Nephrology CHU de Brest Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9gine","family":"Ricard","sequence":"additional","affiliation":[{"name":"Etablissement Francais du Sang CHU de Purpan Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Delas","sequence":"additional","affiliation":[{"name":"Department of Pathology Institut Universitaire du Cancer Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Colombat","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"Department of Pathology Institut Universitaire du Cancer Toulouse 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