{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:37Z","timestamp":1787014057917,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T00:00:00Z","timestamp":1567900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["HHSH250201500009C"],"award-info":[{"award-number":["HHSH250201500009C"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01\u2010DK096008"],"award-info":[{"award-number":["R01\u2010DK096008"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We examined a novel linkage of national US donor registry data with records from a pharmacy claims warehouse (2007\u20102016) to examine associations (adjusted hazard ratio,\n                    <jats:sub>LCL<\/jats:sub>\n                    aHR\n                    <jats:sub>UCL<\/jats:sub>\n                    ) of post\u2010donation fills of antidiabetic medications (ADM, insulin or non\u2010insulin agents) with body mass index (BMI) at donation and other demographic and clinical factors. In 28\u00a0515 living kidney donors (LKDs), incidence of ADM use at 9\u00a0years rose in a graded manner with higher baseline BMI: underweight, 0.9%; normal weight, 2.1%; overweight, 3.5%; obese, 8.5%. Obesity was associated with higher risk of ADM use compared with normal BMI (aHR,\n                    <jats:sub>3.36<\/jats:sub>\n                    4.59\n                    <jats:sub>6.27<\/jats:sub>\n                    ). Metformin was the most commonly used ADM and was filled more often by obese than by normal weight donors (9\u2010year incidence, 6.87% vs 1.85%, aHR,\n                    <jats:sub>3.55<\/jats:sub>\n                    5.00\n                    <jats:sub>7.04<\/jats:sub>\n                    ). Insulin use was uncommon and did not differ significantly by BMI. Among a subgroup with BMI data at the 1\u2010year post\u2010donation anniversary (n\u00a0=\u00a019\u00a0528), compared with stable BMI, BMI increase &gt;0.5\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    by year 1 was associated with increased risk of subsequent ADM use (aHR,\n                    <jats:sub>1.03<\/jats:sub>\n                    1.48\n                    <jats:sub>2.14,<\/jats:sub>\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.04). While this study did not assess the impact of donation on the development of obesity, these data support that among LKD, obesity is a strong correlate of ADM use.\n                  <\/jats:p>","DOI":"10.1111\/ctr.13696","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T12:02:50Z","timestamp":1566043370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Associations of obesity with antidiabetic medication use after living kidney donation: An analysis of linked national registry and pharmacy fill records"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-4849","authenticated-orcid":false,"given":"Krista L.","family":"Lentine","sequence":"first","affiliation":[{"name":"Center for Abdominal Transplantation Saint Louis University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrukh M.","family":"Koraishy","sequence":"additional","affiliation":[{"name":"Center for Abdominal Transplantation Saint Louis University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6084-8677","authenticated-orcid":false,"given":"Nagaraju","family":"Sarabu","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University Hospitals Cleveland Medical center Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1602-9425","authenticated-orcid":false,"given":"Abhijit S.","family":"Naik","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan N.","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit X.","family":"Garg","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5684-0613","authenticated-orcid":false,"given":"David","family":"Axelrod","sequence":"additional","affiliation":[{"name":"University of Iowa Transplant Institute University of Iowa School of Medicine Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1084-9732","authenticated-orcid":false,"given":"Zidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Abdominal Transplantation Saint Louis University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8942-6865","authenticated-orcid":false,"given":"Gregory P.","family":"Hess","sequence":"additional","affiliation":[{"name":"Drexel College of Medicine Drexel University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram L.","family":"Kasiske","sequence":"additional","affiliation":[{"name":"Department of Medicine Hennepin County Medical Center Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorry L.","family":"Segev","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4239-1252","authenticated-orcid":false,"given":"Macey L.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan B.","family":"Massie","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5808-5954","authenticated-orcid":false,"given":"Courtenay M.","family":"Holscher","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Schnitzler","sequence":"additional","affiliation":[{"name":"Center for Abdominal Transplantation Saint Louis University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,8]]},"reference":[{"issue":"8","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/TP.0000000000001770","article-title":"KDIGO clinical practice guideline on the evaluation and care of living kidney donors","volume":"101","author":"Lentine KL","year":"2017","journal-title":"Transplantation"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13917"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015091018"},{"key":"e_1_2_8_5_1","unstructured":"OPTN (Organ Procurement and Transplantation Network)\/UNOS (United Network for Organ Sharing).OPTN Policies Policy 14: Living Donation.http:\/\/optn.transplant.hrsa.gov\/governance\/policies\/. Accessed July 7 2019."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.13.1581"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-1-200601030-00006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510491"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.10.014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.07.015"},{"issue":"6","key":"e_1_2_8_11_1","first-page":"S53","article-title":"A report of the amsterdam forum on the care of the live kidney donor: data and medical guidelines","volume":"79","author":"Delmonico F","year":"2005","journal-title":"Transplantation"},{"key":"e_1_2_8_12_1","unstructured":"The British Transplant Society and The Renal Association.The United Kingdom Guidelines for Living Donor Kidney Transplantation.4thed. 2018."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu216"},{"issue":"2","key":"e_1_2_8_14_1","first-page":"1","article-title":"Recommendations for living\u2010donor kidney transplantation","volume":"30","author":"Spanish Society of Nephrology (S.E.N.) and Spanish Transplant Organisation (ONT)","year":"2010","journal-title":"Nefrologia"},{"key":"e_1_2_8_15_1","unstructured":"AST Live Donor Community of Practice.Live Kidney Donor Medical Toolkit for Medical Providers. The Obese Kidney Donor.https:\/\/www.myast.org\/patient-information\/live-donor-toolkit. Accessed July 7 2019."},{"issue":"3","key":"e_1_2_8_16_1","first-page":"293","article-title":"European renal best practice guideline on the management and evaluation of the kidney donor and recipient","volume":"34","author":"Pascual J","year":"2014","journal-title":"Nefrologia"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2009.01221.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000136654.85459.1E"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14519"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13302"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365157"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12599"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14033"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381291"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.01.017"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08530813"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000248"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2014.11.064"},{"key":"e_1_2_8_29_1","unstructured":"Center For Disease Control.Prevalence of Obesity Among Adults and Youth: United States 2015\u20132016.2017;2018(December 18)https:\/\/www.cdc.gov\/nchs\/data\/databriefs\/db288.pdf. Accessed July 7 2019."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000950"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02944.x"},{"key":"e_1_2_8_32_1","unstructured":"Centers for Disease Control and Prevention.Diabetes Report Card 2017.https:\/\/www.cdc.gov\/diabetes\/pdfs\/library\/diabetesreportcard2017-508.pdf. Accessed July 7 2019."},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12608"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04321.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-s064"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2441"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.5294"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1299"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.11.004"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-7-199504010-00001"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-201407151-01648"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13360"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016050571"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.13696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T04:59:50Z","timestamp":1694235590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,8]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/ctr.13696"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13696","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,8]]},"assertion":[{"value":"2019-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13696"}}