{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:27:56Z","timestamp":1783636076963,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Distinct histopathologic changes occur in acute cellular rejection (ACR), antibody\u2010mediated rejection (AMR), and biopsy\u2010negative rejection (BNR). Cardiovascular magnetic resonance (CMR)\u2010based myocardial tissue characterization can be used to quantify these changes. We assessed T1, T2, and extracellular volume fraction (ECV) by CMR in patients with subtypes of rejection. T1, T2, and ECV were quantified at the mid\u2010ventricular level and compared between patients with and without rejection. The association between quantitative tissue characteristics and the combined outcome of death, retransplantation, heart failure hospitalization, or myocardial infarction was evaluated with a Cox\u2010proportional hazards model. In 46 patients, mean age 53.3\u00a0\u00b1\u00a013.7\u00a0years, 71.7% male, at a median of 7.4\u00a0years from transplant, average myocardial T1 was increased in BNR compared with no rejection (1057 vs 1012\u00a0msec, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). Average myocardial T2 was elevated in all types of rejection, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05. In a cox\u2010proportional hazards model, higher T2 values were associated with an increase in the combined clinical outcome (adjusted HR 1.21, 95% CI 1.06\u20101.37, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) after adjusting for left ventricular mass index. Myocardial tissue characteristics are abnormal in all subtypes of rejection, and abnormal T2 quantified by CMR provides additional prognostic value.<\/jats:p>","DOI":"10.1111\/ctr.13704","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T06:19:17Z","timestamp":1567145957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quantitative myocardial tissue characterization by cardiac magnetic resonance in heart transplant patients with suspected cardiac rejection"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4676-2433","authenticated-orcid":false,"given":"Robert J. H.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Imaging, Mark Taper Imaging Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Thomson","sequence":"additional","affiliation":[{"name":"Department of Imaging, Mark Taper Imaging Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Levine","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia J.","family":"Dimbil","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jignesh","family":"Patel","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon A.","family":"Kobashigawa","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-2412","authenticated-orcid":false,"given":"Evan","family":"Kransdorf","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debiao","family":"Li","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research 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