{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:24:32Z","timestamp":1769761472189,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anticoagulation in heart transplant (HT) recipients increases the risk of hemorrhagic complications, so correct reversal of anticoagulation is needed. Dabigatran, a direct thrombin inhibitor, is increasingly used for anticoagulation in patients with non\u2010valvular atrial fibrillation (NVAF) whose effect can be reversed by idarucizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To present a nationwide experience using idarucizumab for the urgent reversal of dabigatran before HT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicenter observational study in 12 Spanish centers to analyze the clinical outcomes after using idarucizumab before HT surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three patients were included (81.1% male). 7.5% required re\u2010operation in the immediate postoperative period to control bleeding and 66% transfusion of blood products. Median length of stay in the intensive care unit was 6\u00a0days and total hospital stay 24\u00a0days. 30\u2010day survival was 92.4%. There were four deaths in the first month, all in the first 5\u00a0days post\u2010HT. Only in one patient (transplanted due to a congenital heart disease, after sternotomy) who had surgical problems and right ventricular failure post\u2010HT death was associated with bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results may support the use of dabigatran as an alternative to vitamin K antagonists in patients listed for HT requiring anticoagulation due to NVAF. More studies are needed to reaffirm these observations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13748","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T13:33:39Z","timestamp":1572528819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Use of Idarucizumab to reverse the anticoagulant effect of dabigatran in cardiac transplant surgery. A multicentric experience in Spain"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4886-5615","authenticated-orcid":false,"given":"Maria G.","family":"Crespo\u2010Leiro","sequence":"first","affiliation":[{"name":"Unidad de Insuficiencia Card\u00edaca y Trasplante Servicio de Cardiolog\u00eda Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC) Complejo Hospitalario Universitario de A Coru\u00f1a (CHUAC) Universidade Da Coru\u00f1a (UDC) A Coru\u00f1a Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"L\u00f3pez\u2010Vilella","sequence":"additional","affiliation":[{"name":"Unidad de Insuficiencia Card\u00edaca y Trasplante Servicio de Cardiolog\u00eda Hospital Universitari i Polit\u00e8cnic La Fe Valencia 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