{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:26:33Z","timestamp":1760955993352,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL007854"],"award-info":[{"award-number":["T32 HL007854"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Continuous\u2010flow mechanical circulatory support (CF\u2010MCS) is associated with impaired vascular function and increased risk of vasoplegia. One contributing factor to early graft failure (EGF) is severe vasoplegia. We tested the hypothesis that CF\u2010MCS is associated with increased risk of EGF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult primary heart transplant recipients in the ISHLT Registry from 2005 to 2013 were stratified into three groups based on pre\u2010transplant MCS: No MCS (n\u00a0=\u00a011\u00a0748), pulsatile (P)\u2010MCS (n\u00a0=\u00a0718), and CF\u2010MCS (n\u00a0=\u00a03818). EGF was defined as death\/retransplantation due to graft failure within 30\u00a0days after HT. Comparisons were made using descriptive statistics and associations. EGF was assessed with multivariable Cox proportional hazard regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of EGF within 30\u00a0days was similar between groups (No MCS 2.2%, P\u2010MCS 3.3%, CF\u2010MCS 2.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.10). Following multivariable adjustment, the risk of EGF was not statistically different for those with CF\u2010MCS compared with P\u2010MCS (HR 0.75, 95% CI 0.46\u20101.21, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.24). The risk of EGF was numerically, but not statistically significantly higher for CF\u2010MCS compared with No MCS (HR 1.24, 95% CI 0.92\u20101.67, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.16).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CF\u2010MCS use was not associated with a statistically significant increased risk of EGF resulting in death or retransplantation in the first 30\u00a0days after transplant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13752","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T13:42:18Z","timestamp":1573047738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Continuous\u2010flow mechanical circulatory support is not associated with early graft failure: An analysis of the International Society for Heart and Lung Transplantation registry"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8351-9219","authenticated-orcid":false,"given":"Kevin J.","family":"Clerkin","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Cardiology Columbia University College of Physicians and Surgeons New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Stehlik","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wida S.","family":"Cherikh","sequence":"additional","affiliation":[{"name":"United Network for Organ Sharing Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars H.","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Medicine Karolinska Institutet &amp; Heart and Vascular Theme Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.08.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.03.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02644-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2009.06.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2007.72"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-199709000-00073"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.07.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017647"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.969873"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2001.025005371.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.04.012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.11.439"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.08.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.02.027"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.721"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.07.009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.03.004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.12.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.05.066"},{"issue":"1","key":"e_1_2_8_21_1","first-page":"200","article-title":"Mechanical circulatory support after heart transplantation()","volume":"41","author":"Mihaljevic T","year":"2012","journal-title":"Eur J Cardiothoraci Surg"},{"issue":"2","key":"e_1_2_8_22_1","first-page":"343","article-title":"Extra\u2010corporeal membrane oxygenation temporary support for early graft failure after cardiac transplantation","volume":"37","author":"D'Alessandro C","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12793"},{"issue":"6","key":"e_1_2_8_24_1","first-page":"1348","article-title":"Incidence and outcome of Levitronix CentriMag support as rescue therapy for early cardiac allograft failure: a United Kingdom national study","volume":"40","author":"Thomas HL","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-007-0070-9"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.060"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13752","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.13752","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T13:50:31Z","timestamp":1694181031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,26]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/ctr.13752"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13752","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2019,11,26]]},"assertion":[{"value":"2019-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13752"}}