{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T22:53:47Z","timestamp":1756076027793,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bloodstream infection (BSI) is a life\u2010threatening complication after living donor liver transplantation (LDLT). We aimed to explore the incidence and predisposing factors of BSI at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort analysis on all consecutive adults with BSI within 6\u00a0months after LDLT performed between 2005 and 2016. For antimicrobial prophylaxis, ampicillin\/sulbactam, cefotaxime, and micafungin were administered. From 2011, methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) carriers were decolonized using mupirocin ointment and chlorhexidine gluconate soap. Risk factors for BSI were identified by uni\u2010 and multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of a total of 106 LDLTs, 42 recipients (40%) suffered BSI. The BSI group demonstrated significantly higher in\u2010hospital mortality rates compared with the non\u2010BSI group (24% vs. 7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). We identified MRSA carrier (odds ratio [OR], 19.1; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), ABO incompatibility (OR, 2.9; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), and estimated glomerular filtration rate &lt;30\u00a0mL\/min\/1.73m<jats:sup>2<\/jats:sup> (OR, 15.8; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) as independent risk factors for BSI. Decolonization treatment for MRSA carriers did not reduce the incidence of all\u2010cause BSI but reduced the frequency of BSI caused by MRSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, for the first time, MRSA carriers were revealed to be highly vulnerable to BSI after LDLT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13753","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T12:22:38Z","timestamp":1573042958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Methicillin\u2010resistant <i>Staphylococcus aureus<\/i> carriers are vulnerable to bloodstream infection after living donor liver transplantation"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-9902","authenticated-orcid":false,"given":"Yusuke","family":"Takemura","sequence":"first","affiliation":[{"name":"Department of Surgery Keio 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