{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:34:10Z","timestamp":1793136850895,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bridging heart failure patients with mechanical ventricular assist devices (VAD) enables access to transplantation. However, VAD is associated with increased risk for anti\u2010HLA antibodies associated with rejection of subsequent allografts. Factors determining alloantibody formation in these patients remain undefined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center retrospective cohort study of 164 patients undergoing heart transplantation from 2014 to 2017. Medical records including use of VAD, transfused blood products, anti\u2010HLA antibody testing, crossmatch, and time to transplant were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients received an average of 13.8 red blood cell and 1.9 single\u2010donor platelet units associated with VAD. There was a 28.7% increase in the incidence of anti\u2010HLA antibodies after VAD. Development of anti\u2010HLA antibodies did not correlate with volume or type of blood products, but with pre\u2010VAD HLA sensitization status; relative risk of new alloantibodies in patients with pre\u2010VAD antibodies was 3.5\u2010fold higher than those without prior antibodies (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008). Development of new anti\u2010HLA antibodies was associated with an increased time to transplant (169 vs 330\u00a0days, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that the presence of anti\u2010HLA antibodies pre\u2010VAD was the most significant risk factor for developing additional antibodies post\u2010VAD, suggesting that a subset of patients may be predisposed to alloantibody formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13772","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T08:24:37Z","timestamp":1576571077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Factors influencing transfusion\u2010associated HLA sensitization in patients bridged to heart transplantation using ventricular assist device"],"prefix":"10.1111","volume":"34","author":[{"given":"Jae","family":"Elkind","sequence":"first","affiliation":[{"name":"Department of Pathology University of California, San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Sobczyk","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California, San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Ostberg\u2010Braun","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Silva Enciso","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1097-4453","authenticated-orcid":false,"given":"Gerald P.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California, San Diego La Jolla CA 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