{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:53:29Z","timestamp":1764172409405,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["234\u20102005\u2010370011C"],"award-info":[{"award-number":["234\u20102005\u2010370011C"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While lung transplantation (LTx) has been effective for connective tissue disease (CTD) patients with pulmonary involvement, outcomes for heart\u2010lung transplantation (HLTx) are less defined. The aim of this study is to evaluate HLTx in CTD patients utilizing the UNOS database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HLTx patients with CTD (HLTx\u2010CTD) were compared to both LTx patients with CTD (LTx\u2010CTD) and HLTx patients with all other indications (HLTx\u2010OI) from 1999 to 2018. Primary outcome was 1\u2010 and 5\u2010year graft survival. Secondary outcomes included freedom from first\u2010year rejection and outcomes prior to transplant discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1143\/29\u00a0323 adults received first\u2010time HLTx or LTx for CTD. Seventeen were HLTx\u2010CTD (3.3% of total HLTx) and 1126 were LTx\u2010CTD (3.9% of total LTx). There were 492 HLTx\u2010OI. Transplant hemodynamic values including cardiac output, pulmonary capillary wedge pressure, and calculated pulmonary vascular resistance were significantly worse for HLTx\u2010CTD vs LTx\u2010CTD (4.2 vs 5.4\u00a0L\/min, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005; 14 vs 10\u00a0mm\u00a0Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.009; 439 vs 267 dynes, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007, respectively). Cardiac status 1 was more common for HLTx\u2010CTD vs HLTx\u2010OI (94% vs 56%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). HLTx\u2010CTD 1 and 5\u2010year graft survival was similar compared to LTx\u2010CTD and HLTx\u2010OI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HLTx\u2010CTD is a valid option for carefully selected patients with CTD cardiac and pulmonary involvement with similar morbidity and mortality compared to LTx\u2010CTD and HLTx\u2010OI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13776","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T09:59:42Z","timestamp":1577095182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Heart\u2010lung transplantation: A viable option for connective tissue diseases"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-9563","authenticated-orcid":false,"given":"Lily K.","family":"Stern","sequence":"first","affiliation":[{"name":"Department of Medicine University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van N.","family":"Selby","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-959X","authenticated-orcid":false,"given":"Nicholas A.","family":"Kolaitis","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Department of Medicine University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Boin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandar","family":"Aras","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0547-1480","authenticated-orcid":false,"given":"Liviu","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"De Marco","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1140"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.12.079"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2005.04.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-017-0650-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.01.020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201503-177OC"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182845f23"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001792"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.3796"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-014-0488-6"},{"key":"e_1_2_8_12_1","first-page":"578390","article-title":"Aggressive 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