{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:32:37Z","timestamp":1792726357422,"version":"4.5.0"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to investigate the association between social behaviors of increased\u2010risk donors (IRD) and recipient outcomes after heart transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The United Network for Organ Sharing (UNOS) database was queried to identify patients who received a heart transplant between 2004 and 2015. Patients were grouped based on donor's risk status (IRD vs standard risk donor [SRD]). Recipients of IRD were categorized based on donor social behaviors (SB), and recipient survival was assessed. Cox regression analysis was used to identify associations between SB of donors and recipient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 22\u00a0333 heart transplantations performed during the study period, 2769 (12%) received an IRD graft with the following SB: Unprofessional tattoos or piercings (n\u00a0=\u00a01722) (63%), cocaine use (n\u00a0=\u00a0916) (33%), heavy smoking (n\u00a0=\u00a0437) (16%), and heavy alcohol abuse (n\u00a0=\u00a0610) (22%). Viral screens detected 72(3%) hepatitis B virus (HBV) positive and 12 (0.4%) hepatitis C virus (HCV) positive at donation. There was no difference in recipient survival based on both donor risk and their social behaviors. Cox regression analysis found only donor HCV infection and non\u2010identical ABO mismatch to be associated with poor recipient survival among recipients of IR grafts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cardiac allografts from IRD, serologically negative for viruses, can safely be used. There is no association between social behaviors of IRD and recipient survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13787","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T11:19:56Z","timestamp":1579605596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between increased\u2010risk donor social behaviors and recipient outcomes after heart transplantation"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8890-3332","authenticated-orcid":false,"given":"Alexis K.","family":"Okoh","sequence":"first","affiliation":[{"name":"Cardiovascular Outcomes Research Institute RWJ Barnabas Health Heart Centers NBIMC Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Chan","sequence":"additional","affiliation":[{"name":"Cardiovascular Outcomes Research Institute RWJ Barnabas Health Heart Centers NBIMC Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Schultheis","sequence":"additional","affiliation":[{"name":"Cardiovascular Outcomes Research Institute RWJ Barnabas Health Heart Centers NBIMC Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitalie","family":"Gupta","sequence":"additional","affiliation":[{"name":"Cardiovascular Outcomes Research Institute RWJ Barnabas Health Heart Centers NBIMC Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakash","family":"Shah","sequence":"additional","affiliation":[{"name":"Cardiovascular Outcomes Research Institute RWJ Barnabas Health Heart Centers NBIMC Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Gold","sequence":"additional","affiliation":[{"name":"Cardiovascular Outcomes Research Institute RWJ Barnabas Health Heart Centers NBIMC Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Russo","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Camacho","sequence":"additional","affiliation":[{"name":"Cardiovascular Outcomes Research Institute RWJ Barnabas Health Heart Centers NBIMC Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12861"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ca56e0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.12.062"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2016.01.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.12.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu512"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.01.1293"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.06.012"}],"container-title":["Clinical 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