{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:44:49Z","timestamp":1777869889461,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The risk of subsequent cytomegalovirus infection (CMV) in kidney transplant recipients (KTR) after diagnosis of BK polyomavirus viremia (BKV) is unclear, and current evidence is conflicting. We reviewed all KTR transplanted at our institution between 1\/1\/2005 and 12\/31\/2015. Follow\u2010up began 3\u00a0months after transplantation to avoid confounding effects of prophylaxis. Clinically significant BKV, defined as detectable BK viremia &gt;1000\u00a0copies\/mL via molecular diagnostic testing (PCR), was treated as a time\u2010varying exposure with 1\u2010year follow\u2010up. This viral load cutoff was chosen to ensure a more homogenous population that would be considered to have clinically significant BK viremia that necessitated management via immunosuppressive modification. Patients were then screened for subsequent CMV infection. 2435 RTX recipients met inclusion criteria; of these, 314 developed BKV during follow\u2010up (BK+). Lymphocyte depletion, tacrolimus maintenance, and biopsy\u2010proven rejection were significantly higher in the BK+ group. BK+ was associated with lower risk of subsequent CMV infection (BK+ HR 0.45, 95% CI 0.22\u20100.94, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03, relative risk reduction 55%). When adjusted for significant confounding factors, CMV incidence remained reduced in the BK+ population (HR 0.47, 95% CI 0.22\u20100.98, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). This large series of KTR demonstrates that BKV is associated with lower risk of subsequent CMV infection.<\/jats:p>","DOI":"10.1111\/ctr.13798","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T10:22:31Z","timestamp":1580293351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Management of BK viremia is associated with a lower risk of subsequent cytomegalovirus infection in kidney transplant recipients"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-9727","authenticated-orcid":false,"given":"Margaret R.","family":"Jorgenson","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Wisconsin Hospital and Clinics Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian L.","family":"Descourouez","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Wisconsin Hospital and Clinics Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beini","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Population Health Sciences University of Wisconsin Madison School of Medicine and Public Health Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad C.","family":"Astor","sequence":"additional","affiliation":[{"name":"Department of Medicine and Population Health Sciences University of Wisconsin Madison School of Medicine and Public Health Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Saddler","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison School of Medicine and Public Health Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-8583","authenticated-orcid":false,"given":"Didier A.","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison School of Medicine and Public Health Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7465","authenticated-orcid":false,"given":"Sandesh","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison School of Medicine and Public Health Madison WI 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