{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:34:14Z","timestamp":1762868054962,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["F32DK113719","K01DK101677","K23DK115908"],"award-info":[{"award-number":["F32DK113719","K01DK101677","K23DK115908"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A number of deceased donor kidney scoring systems have been developed to predict post\u2010transplant graft failure. However, studies comparing the predictive ability of these scoring systems to each other are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used single\u2010center histopathologic and UNOS data from 140 marginal deceased donor kidneys and transplant recipients to compare the predictive accuracy of the Maryland Aggregate Pathology Index (MAPI), Kidney Donor Risk Index (KDRI), Remuzzi, and Nyberg scoring systems for 2\u2010year graft survival using time\u2010dependent receiver operating curves and Kaplan\u2010Meier analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MAPI had the highest predictive accuracy (area under curve [AUC]\u00a0=\u00a00.81) compared to KDRI (AUC\u00a0=\u00a00.45), Remuzzi (AUC\u00a0=\u00a00.59), and Nyberg (AUC\u00a0=\u00a00.63) for 2\u2010year graft survival. Furthermore, when analyzing each score according to its pre\u2010defined risk strata, MAPI was the only scoring system for which 2\u2010year graft survival was significantly different across strata (84.3% for low risk, 56.5% for intermediate risk, and 50% for high risk, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Additionally, MAPI was the only risk score significantly associated with 2\u2010year graft survival (hazard ratio per point: 1.12, 95% confidence interval [CI]: 1.01\u20101.23, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a single\u2010center cohort of biopsied marginal kidneys used for transplantation, MAPI had the best predictive ability of these four scoring systems. When biopsy data are available for kidneys considered for transplantation, the MAPI score may provide additional information that could be used to better identify kidneys likely to have longer graft survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13802","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T17:05:33Z","timestamp":1580403933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["What's the score? A comparison of deceased donor kidney scoring systems and correlation with graft outcome"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-5377","authenticated-orcid":false,"given":"Kyle R.","family":"Jackson","sequence":"first","affiliation":[{"name":"Department of Surgery Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghava B.","family":"Munivenkatappa","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell N.","family":"Wesson","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University School of Medicine Baltimore 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