{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:00Z","timestamp":1753878420942,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with diabetes mellitus treated with successful pancreas transplantation (PTX) normalize hyperglycemia, but are exposed to immunosuppressive drugs that may impair endothelial function. This study aimed to evaluate endothelial function in single PTX recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Flow\u2010mediated dilatation (FMD) in the brachial artery was measured by ultrasound 8\u00a0weeks after transplantation in single PTX (n\u00a0=\u00a027) and compared with healthy controls (n\u00a0=\u00a058), simultaneous pancreas and kidney recipients (n\u00a0=\u00a09), and kidney transplant recipients with (n\u00a0=\u00a041) and without (n\u00a0=\u00a095) diabetes mellitus. Adjustments for age, gender, blood pressure, and body mass index were included in a linear regression model. Changes in FMD from before to 1\u00a0year after transplantation were assessed in a subgroup of PTX recipients (n\u00a0=\u00a09).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Flow\u2010mediated dilatation% in PTX recipients was not inferior to healthy controls (8.7\u00a0\u00b1\u00a03.6 vs 7.7\u00a0\u00b1\u00a03.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.06) and simultaneous pancreas and kidney recipients (6.7\u00a0\u00b1\u00a04.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.24) in an adjusted model, and superior to kidney recipients with and without diabetes (3.0\u00a0\u00b1\u00a03.0 and 4.8\u00a0\u00b1\u00a03.3, respectively, both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.005). FMD% improved significantly from eight weeks to one year after PTX, mean 7.9\u00a0\u00b1\u00a04.2% vs 11.8\u00a0\u00b1\u00a04.8% (N\u00a0=\u00a09; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Flow\u2010mediated dilatation is well preserved in patients undergoing pancreas transplantation and is not impaired when immunosuppressive drugs are introduced.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13815","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T15:42:25Z","timestamp":1581003745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endothelial function after pancreas transplantation\u2014A single\u2010center observational 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Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rune","family":"Horneland","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Section of Transplant Surgery Oslo University Hospital, Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trond Geir","family":"Jenssen","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Section of Nephrology Oslo University Hospital, Rikshospitalet Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Metabolic and Renal Research Group Faculty of Health Sciences UiT\u2010 The Arctic University of Norway Troms\u00f8 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