{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:54:29Z","timestamp":1789401269274,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early conversion from a calcineurin inhibitor to belatacept has the potential to improve long\u2010term renal allograft function; however, there remains limited experience with this strategy among African Americans and patients with preformed donor\u2010specific antibodies (DSA). To examine these subgroups, we performed a single\u2010center review of kidney transplant recipients converted to belatacept within 1\u2010year of transplant between 01\/2011 and 10\/2017. All patients received lymphocyte\u2010depleting induction with maintenance tacrolimus and mycophenolate +\/\u2212 corticosteroids. Patients were switched to belatacept for clinical indication and followed from date of conversion until allograft failure or study conclusion. The primary endpoint at 1\u2010year was a composite of allograft loss, biopsy proven rejection, de novo DSA formation, proteinuria, and declining renal function. Thirty\u2010two patients were included in the review. The majority were African American, and 28.1% had DSA at transplant. Patient and allograft survival at 1\u2010year was 96.9% and 93.8%, respectively, and estimated glomerular filtration rate improved from 41.9 to 58.4\u00a0mL\/min. No African Americans or patients with pretreatment DSA developed rejection or allograft failure within 1\u2010year. The only clinical variable correlated with suboptimal allograft function was baseline weight \u226580\u00a0kg (OR\u00a0=\u00a06.2; 95% CI, 1.2\u201032.3). Early conversion to belatacept appears safe for select patients with DSA and African Americans receiving lymphocyte\u2010depleting induction.<\/jats:p>","DOI":"10.1111\/ctr.13823","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T16:30:06Z","timestamp":1581525006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Conversion to belatacept within 1\u2010year of renal transplantation in a diverse cohort including patients with donor\u2010specific antibodies"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4575-5330","authenticated-orcid":false,"given":"Andrew D.","family":"Santeusanio","sequence":"first","affiliation":[{"name":"Recanati\u2010Miller Transplantation Institute Mount Sinai Hospital New York NY USA"},{"name":"Department of Pharmacy Mount Sinai Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Bhansali","sequence":"additional","affiliation":[{"name":"Recanati\u2010Miller Transplantation Institute Mount Sinai Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Population Health Science and Policy Mount Sinai Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Recanati\u2010Miller Transplantation Institute Mount Sinai Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Delaney","sequence":"additional","affiliation":[{"name":"Recanati\u2010Miller Transplantation Institute Mount Sinai Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1635-9136","authenticated-orcid":false,"given":"Sander","family":"Florman","sequence":"additional","affiliation":[{"name":"Recanati\u2010Miller Transplantation Institute Mount Sinai Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"De Boccardo","sequence":"additional","affiliation":[{"name":"Recanati\u2010Miller Transplantation Institute Mount Sinai Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02414.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00007.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00332.x"},{"key":"e_1_2_9_5_1","first-page":"355","article-title":"Introduction to the use of belatacept: a fusion protein for the prevention of posttransplant kidney rejection","volume":"6","author":"Ippoliti 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